THE STUDY OF CERIUM COMPOUNDS’ EFFECT ON POST-BURN SCAR TISSUE MATURATION IN THE IN VIVO EXPERIMENT

DOI: https://doi.org/10.29296/25877313-2018-10-03
Issue: 
10
Year: 
2018

O.A. Legon’kova Dr.Sc. (Eng.), Head of the Department of Dressing, Suture and Polymer Materials in Surgery, National Medical Research Center of Surgery named after A.V. Vishnevsky of the Ministry of Health of the Russian Federation (Moscow) E-mail: Legonkova@ixv.ru A.I. Korotaeva Junior Research Scientist, Department of Dressing, Suture and Polymer Materials in Surgery, National Medical Research Center of Surgery named after A.V. Vishnevsky of the Ministry of Health of the Russian Federation (Moscow) S.A. Ukhin Surgeon, Department of Reconstructive Plastic Surgery, National Medical Research Center of Surgery named after A.V. Vishnevsky of the Ministry of Health of the Russian Federation (Moscow) I.A. Chekmareva Dr.Sc. (Biol.), Head of the Laboratory of Electron Microscopy, National Medical Research Center of Surgery named after A.V. Vishnevsky of the Ministry of Health of the Russian Federation (Moscow) T.V. Fedorova Leading Research Scientist, Institute of Biochemistry named after A.N. Bach of the Russian Academy of Sciences (Moscow) E.O. Landesman Engineer, Institute of Biochemistry named after A.N. Bach of the Russian Academy of Sciences (Moscow) M.A. Teplonogova Senior Laboratory Research, Institute of General and Inorganic Chemistry named after. N.S. Kurnakov of the Russian Academy of Sciences (Moscow) A.E. Baranchikov Ph.D. (Chem.), Head of the Laboratory of Functional Materials Synthesis and Mineral Processing, Institute of General and Inorganic Chemistry named after. N.S. Kurnakov of the Russian Academy of Sciences (Moscow) V.K. Ivanov Dr.Sc. (Chem.), Corresponding Member of the Russian Academy of Sciences, Director of the Institute of General and Inorganic Chemistry named after. N.S. Kurnakov of the Russian Academy of Sciences (Moscow)

Previously, we have experimentally confirmed the nanodispersed cerium dioxide (NDC) regenerative properties during burn injury repair. The aim of the present research was to continue the cycle of surveys on biological properties of cerium compounds and to study their effect on post-burn scar deformities, treatment of which is still one of serious problems in reconstructive and plastic surgery. So, experimental studies were conducted in vivo to evaluate the effect of cerium compounds in different concentrations on post-burn scar tissue. The results of the research indicate that cerium compounds, both in the nanodisperse form and in the form of water-soluble salt, have a tissue-preserving and anti-inflammatory effects, provide the formation of more complete regenerate compared to the control, while the regeneration ability of tissues adjacent to the primary burn injury is improved. Injection forms of cerium compounds can be used in concentrations of 0.05 and 0.5 % by weight. Cerium compounds are promising for medical application due to its low cytotoxicity and wound healing properties. But, the revealed effect of the penetration of cerium compounds into connective tissue cells suggests further surveys of the mechanisms of its influence at the stage of wound healing.

Keywords: 
nanodisperse cerium dioxide (NDC)
cerium chloride (III)
burn injury
anti-inflammatory effect
scar tissue

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