THE EFFECT OF THE JOINT USE OF TWO ANTITHROMBOTIC DRUGS LONGITIN AND PIYAVIT IN EXPERIMENTS IN VIVO

We studied the interaction of two antithrombin preparations: experimental complex of proteinases Longolytin from an anamorphic fungus Ar-throbotrys longa (rectal application) and commercial preparation Pijavitum from the medical leech Hirudo medicinalis (oral administration) in experiments in vivo on 44 mongrel rats in for 6 days. The data were compared with the results obtained in the individual usage of these drugs. One of the objectives of our the study was to increase the effectiveness of Longolitin as a thrombolytic and antithrombotic drug by adding to it synergistic substances. Among them, we chose to study the Russian drug Piyavit, which has antithrombotic and anticoagulant properties and is used in medicine to improve blood rheology. Separate administration of Longolitine showed moderate activation of fibrinolysis, increasing after discontinuation of the drug by the 12th day, and an increase in anticoagulant and antipolymerization activity by the 6th day. Piyavit's individual use also activated fibrinolysis by day 12 and significantly in-creased the polymerization and anticoagulant properties of blood. When drugs were used together, the plasma anticoagulant activity was slightly potentiat-ed compared with the administration of Longolitine alone. Plasma fibrinolytic activity slightly increased by the 6th day, but significantly and reliably inhibited after drug withdrawal by the 12th day, which is unfavorable for the prevention of thrombosis.