SOME ASPECTS OF PRE-CLINICAL STUDIES OF HERACLEUM L. SPECIES: REVIEW OF PUBLICATIONS

DOI: https://doi.org/10.29296/25877313-2018-10-20
Issue: 
10
Year: 
2018

Т.B. Tanirbergenov Ph.D. (Biol), Leading Research Scientist, All-Russian State Center for the Quality and Standardization of Medicines for Animals and Feeds (Moscow) E-mail: ttanirbergenov@vgnki.ru A.E. Babushkina Deputy Head of the Department of Internal Veterinary Oversight, Federal Service for Veterinary and Phytosanitary Supervision (Rosselkhoznadzor) E-mail: anna_eva99@mail.ru N.S. Vasyukova Specialist, All-Russian State Center for the Quality and Standardization of Medicines for Animals and Feeds (Moscow) E-mail: n.vasukova@vgnki.ru

Objectives: The objectives of the study were to systematize published data on preclinical, including toxicology, studies of Heracleum species and biologically active substances (BAS’s) isolated from it. Methods: Information search on subject-matter, selection of descriptive and quantitative information, summarization, analysis and interpretation of results. Results: At the data closing point it had been revealed 514 published sources in databases, concerning various aspects of exploring of Heracleum species. It had been found out 31 publications related to preclinical, including toxicology, studies of the main BAS’s in plants of Heracleum genus. The re-sults of original experimental studies of safety and pharmacological activity of water and water-alcohol extracts of different species of Heracleum genus had been analyzed. Conclusions: The results of acute toxicity studies of intragastric administration of water extracts from H. sosnowskyi and H. moellendorffii to experimental animals allow to consider them as low-toxic substances. BAS’s from different Heracleum species can influence on reproductive function of male and female mammals, show mutagenic and embryotoxic properties. Plants of Heracleum genus may be a promising source of substances for development of new drugs for human and veterinary use with spasmolytic, hepatoprotective, antioxidant and hypoglycemic activities.

Keywords: 
Heracleum
phototoxicity
genotoxicity
carcinogenicity
furocoumarins

References: 
  1. Laman N.A., Prohorov V.N., Maslovskij O.M. Gigantskie borscheviki – opasnye invazivnye vidy dlja prirodnyh kompleksov i naselenija Belarusi // Institut eksperimental'noj botaniki im. V.F. Kuprevicha NAN Belarusi. Minsk. 2009. 40 s.
  2. http://mosreg.ru/sobytiya/novosti/news-submoscow/borba-s-borshchevikom-v-podmoskove-kak-budut-izbavlyatsya-ot-sornyaka.
  3. Mathews M.M. Comparative study of the lethal photosensitization of Sarcina lutea by 8-methoxypsoralen and toluidene blue // J. Bacteri-ol. 1963. № 85. R. 322-328.
  4. Ashwood-Smith M.J., Grant E. Conversion of psoralen DNA monoadducts in E. coli to interstrand DNA crosslinks by near-ultraviolet light (320-360 nm). Inability of angelicin to form crosslinks in vivo // Experientia. 1977. № 33. R. 384-386.
  5. Peckler S., Graves B., Kanne D., Rapoport H., Hearst J.E., Kim S.-H. Structure of a psoralen-thymine monoadduct formed in photoreaction with DNA // J. Mol. Biol. 1982. V. 162. № 1. R. 157-172.
  6. Ashwood-Smith M.J., Natarajan A.T., Poulton G.A. Comparative photobiology of pso-ralens // J. Natl. Cancer Inst. 1982. V. 69. № 1. R. 189-197.
  7. Belogurov A.A., Zavilgelsky G.B. Muta-genic effect of furocoumarin monoadducts and cross-links on bacteriophage lambda // Mutat. Res. 1981. V. 84. № 1. R. 11-15.
  8. Averbeck D., Moustacchi E. Decreased photo-induced mutagenicity of mono-functional as opposed to bi-functional
  9. furocoumarins in yeast // Photochem. Photobiol. 1980. № 31. R. 475-478.
  10. Scheney R.L., Hsie A.W. Interaction of 8-methoxypsoralen and near u.v. light causes mutation and cytotoxicity in mammalian cells // Photochem. Photobiol. 1981. V. 33. № 2.
  11. R. 179-185.
  12. Sahar E., Kittrel C., Pulghum S., Peld M., Latt S.A. Sister-chromatid exchange induction in Chinese hamster ovary cells by 8-methoxypsoralen and brief pulses of laser light. Assessment of the relative importance of 8-methoxypsoralen-DNA monoadducts and cross-links // Mutat. Res. 1981. V. 83. № 1. R. 91-105.
  13. Ashwood-Smith M.J. Frameshift mutations in bacteria produced in the dark by several furocoumarins: absence of activity of 4,5,8-trimethylpsoralen // Mutat. Res. 1978. V. 58.
  14. № 1. R. 23-27.
  15. Quinto I., Averbeck D., Moustacchi E., Hrisoho Z., Moron J. Frameshift mutagenicity in Salmonella typhimurium of furocoumarins in the dark // Mutat. Res. 198. V. 136. № 1.
  16. R. 49-54.
  17. Chernjak D. M. Borschevik Sosnovskogo (Heracleum Sosnowskyi Manden.) i Borschevik Mellendorfa (Heracleum Moellendorffii Hance) na juge primorskogo kraja (biologicheskie osobennosti, perspektivy ispol'zovanija i biologicheskaja aktivnost'): Avtoref. diss. … kand. biol. nauk. Vladivostok. 2013. 200 s.
  18. Pesnja D.S., Serov D.A., Vakorin S.A., Prohorova I.M. Issledovanie toksicheskogo, mitozmodifitsirujuschego i mutagennogo dejstvija borschevika Sosnovskogo // Jaro-slavskij ped. vestnik. 2011. T. III. № 4. S. 93-98.
  19. Hemati A., Azarnia M., Nabiuni M., Mira-bolghasemi G., Irian S. Effect of the hydroalco-holic extract of Heracleum persicum (Golpar) on folliculogenesis in female Wistar rats // Cell J. 2012. V. 14. № 1. R. 47-52.
  20. Taghizabet N., Mangoli E., Anbari F., Masoodi S.A., Talebi A.R., Mazrooei M. The effect of heracleum persicum (Golpar) oil and alcoholic extracts on sperm parameters and chromatin quality in mice // Int. J. Reprod. Biomed. (Yazd). 2016. V. 14. № 6. R. 365-370.
  21. Skalicka-Woźniak K., Mendel M., Chło-pecka M., Dziekan N. Isolation and evaluation of the myorelaxant effect of bergapten on isolated rat jejunum // Pharm Biol. 2016. V. 54. № 1. R. 48-54.
  22. Yaman T., Uyar A., Celik I., Alkan E. E., Keles O. F., Yener Z. Histopathological and im-munohistochemical study of antidia-
  23. betic effects of Heracleum persicum extract in experimentally diabetic rats // Ind. J. Pharm. Educ. Res. 2017. V. 51. № 3.
  24. R. S450-S457.
  25. Afrisham R., Aberomand M., Ghaffari M.A., Siahpoosh A., Jamalan M.. Inhibitory effect of Ziziphus jujuba and Heracleum persicum on the activity of partial purified rat intestinal alpha-glucosidase enzyme // J. Mazandaran. Univ. Med. Sci. 2016. V. 26. № 134. R. 135-146 (Persian).
  26. Rostampur S., Hosseinpour Feizi M.A., Banan Khojasteh S.M., Daluchi F. Heracleum persicum extract improves cyclophosphamide-induced liver toxicity and oxidative stress in male rats // Adv. Herb. Med. 2016. V. 2. № 2. R. 29-35