Т.B. Tanirbergenov Ph.D. (Biol), Leading Research Scientist, All-Russian State Center for the Quality and Standardization of Medicines for Animals and Feeds (Moscow) E-mail: A.E. Babushkina Deputy Head of the Department of Internal Veterinary Oversight, Federal Service for Veterinary and Phytosanitary Supervision (Rosselkhoznadzor) E-mail: N.S. Vasyukova Specialist, All-Russian State Center for the Quality and Standardization of Medicines for Animals and Feeds (Moscow) E-mail:

Objectives: The objectives of the study were to systematize published data on preclinical, including toxicology, studies of Heracleum species and biologically active substances (BAS’s) isolated from it. Methods: Information search on subject-matter, selection of descriptive and quantitative information, summarization, analysis and interpretation of results. Results: At the data closing point it had been revealed 514 published sources in databases, concerning various aspects of exploring of Heracleum species. It had been found out 31 publications related to preclinical, including toxicology, studies of the main BAS’s in plants of Heracleum genus. The re-sults of original experimental studies of safety and pharmacological activity of water and water-alcohol extracts of different species of Heracleum genus had been analyzed. Conclusions: The results of acute toxicity studies of intragastric administration of water extracts from H. sosnowskyi and H. moellendorffii to experimental animals allow to consider them as low-toxic substances. BAS’s from different Heracleum species can influence on reproductive function of male and female mammals, show mutagenic and embryotoxic properties. Plants of Heracleum genus may be a promising source of substances for development of new drugs for human and veterinary use with spasmolytic, hepatoprotective, antioxidant and hypoglycemic activities.


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