THE RELATIONSHIP OF THE ACTIVITY OF CASPASE-3, REGULATORS OF APOPTOSIS AND AUTOPHAGY IN HEALTHY YOUNG INDIVIDUALS UNDER THE INFLUENCE OF LOW-INTENSITY RADIATION OF 1 GHZ

Aim. The study of the content in the extracellular environment of the concentration of molecules that determine the state of nonspecific anti-infective resistance in patients undergoing community-acquired pneumonia and practically healthy individuals against the background of whole-blood irra-diation with 1 GHz low-intensity microwaves. Methods. In patients with acute infectious inflammation of the lower respiratory tract and in healthy individuals in the supernatants of whole blood cells was assessed by the content of cathelicidin (LL-37), a protein of neutrophils, which increase membrane permeability (BPI), lipopolysaccharide-binding protein (LBP), myeloperoxidase (MPO), Clara cells protein (CCP), defensin alpha (aD), granzyme (GR) and procathepsin (PC). Results. The results of the study indicate that low-intensity microwave irradiation after 3 hours after exposure is accompanied by an increase in the level of LL-37 by an average of 68.1‰ (p = 0.0001), BPI by 64.1‰ (p = 0.0001), LBP by 101.5‰ (p = 0.00001), MPO by 138.8‰ (p = 0.00001), CCP by 19.8‰ (p = 0.0003), aD by 16.2‰ (p = 0.02), GR by 25.7 (p = 0.0004‰).), a PC 11,1‰ (p = 0,031). 24 hours after exposure, there was a further increase in GR, PC and CCP production. Against this background, there was a reduction in the level of LL-37, BPI, LPS, MPO. Conclusions. Thus, the effects of irradiation on the production of LL-37, BPI, LPS, MPO decrease by the end of the first day from the moment of irradiation, while the production of GR, PC, CCP increases. Thus, irradiation of blood with radiation of 1 GHz frequency promotes activation of neutrophils, macrophages and NK cells with increase of nonspecific anti-infective protection.