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CELL IMMUNITY FOR OVARY CANCER

DOI: https://doi.org/10.29296/25877313-2019-01-01
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1
Year: 
2019

A.I. Chertkova Ph.D. (Med.), Leading Research Scientist, Clinical Laboratory Department, N.N. Blokhin National Medical Research Center of Oncology (Moscow) E-mail: antcher@gmail.com Z.G. Kadagidze Dr.Sc. (Med.), Professor, Leading Research Scientist, Clinical Laboratory Department, N.N. Blokhin National Medical Research Center of Oncology (Moscow) T.N. Zabotina Dr.Sc. (Biol.), Heard of the Clinical Laboratory Department, N.N. Blokhin National Medical Research Center of Oncology (Moscow) N.E. Kushlinskii Dr.Sc. (Med.), Professor, Member of Corresponding of RAS, N.N. Blokhin National Medical Research Center of Oncology (Moscow)

Cytoreductive surgery and chemotherapy of patients with ovarian cancer (OC) provide remission in more than half of the cases, but the vast ma-jority of patients with generalized process after treatment relapse due to the development of resistance to chemotherapy. The mortality rate in OC remains high, that indicates the need for the introduction of new methods of treatment in the existing therapeutic regimens. The immune system plays a significant role in the control of tumor growth. Currently, a sufficient number of clinical studies confirm that OC is an immunogenic tumor and the immune system can recognize and attack the cells of this tumor. The article contains a review of scientific publications devoted to the characteristics of individual populations of effector and regulatory immune cells infiltrating the tumor and their prognostic significance in OC..
Keywords: 
ovarian cancer
lymphocytes
infiltrating tumor
effector and regulatory immune cells

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