ANTIMICROBIAL ACTIVITY OF SOLID EXPERIMENTAL DRUG FORM BASED ON A LIQUID PLANT EXTRACT

DOI: https://doi.org/10.29296/25877313-2019-02-04
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Issue: 
2
Year: 
2019

T.V. Fateeva Chief of the Laboratory of Microbiological Research, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: fateeva2151@mail.ru P.G. Mizina Dr.Sc. (Pharm.), Professor, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) A.S. Gulenkov Post-graduate Student, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)

The data on the study of the antimicrobial activity of an experimental dosage form with a liquid combined plant extract from chamomile flowers, calendula and yarrow herb for resorption in the mouth are presented. It was shown that the natural liquid extract has a higher antibacterial activity against gram-positive bacteria (S. aureus 209-P) than against gram-negative microorganisms and moderate fungistatic activity against mycelial fungi (M. canis). It has been proven that the transfer of a liquid extract into a powdery state, which is necessary for the development of solid dosage forms, by adsorption on carriers of different nature, does not change its antimicrobial properties. At the same time, a decrease in the minimum inhibitory concentration correlates with the degree of release of flavonoids from the carrier surface. The developed experimental dosage form of lozenges has a higher antimicro-bial activity against S. aureus in comparison with the commercial preparations of lozenges «Equivalpt-M» and «Sage», and comparable results in compari-son with the tablets «Echinacea», «Ajisept» and «Strepsils».

Keywords: 
solid dosage form
tablet for resorption in the mouth
antimicrobial activity
bacteriostatic activity
fungistatic activity
liquid plant extract

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