CONTENTS OF VOLATILE FATTY ACIDS IN CONDENSATE OF EXHAUSED AIR IN SMOKING PERSONS

DOI: https://doi.org/10.29296/25877313-2019-04-07
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Issue: 
4
Year: 
2019

T.M. Karavaeva Ph.D. (Med.), Associate Professor, Department of Chemistry and Biochemistry, Chita State Medical Academy E-mail: KaTany1@yandex.ru P.P. Tereshkov Ph.D. (Med.), Leading Research Scientist, Laboratory of Clinical and Experimental Biochemistry and Immunology, Scientific Research Institute of Molecular Medicine, Chita State Medical Academy E-mail: tpp6915@mail.ru M.V. Maximienya Ph.D. (Biol.), Senior Research Scientist, Laboratory of Clinical and Experimental Biochemistry and Immunology, Scientific Research Institute of Molecular Medicine, Chita State Medical Academy E-mail: mmv4510@mail.ru

Smoking annually leads to nearly six million deaths. Exposure of tobacco smoke components to cells leads to significant metabolic shifts, including lipid metabolism disorders. Volatile fatty acids are important biologically active substances, the metabolism of which may be important in the development of bronchopulmonary pathology. Aim. To study the quantitative shifts in the spectrum of short-chain fatty acids in the condensate of exhaled air from smokers. Methods: Gas-liquid chromatography in the condensate of exhaled air was used to determine: C2 – acetic, C3 – propionic, C4 – oil, isoC4 – isobutyr-ic, C5 – valeric, C6 – caproic, C7 – heptane acid. Results. Тhe level of acetate, butyrate, isobutyrate, valerate, heptane increases in the condensate of exhaled air of smokers. As the smoking ex-perience and the number of cigarettes smoked per day increase, the concentration of exhaled volatile fatty acids increases, which may indicate metabolic, physiological disorders in the respiratory organs and, possibly, the beginning of the development of any pathological processes.

Keywords: 
volatile fatty acids
short-chain fatty acids
smoking persons
exhaled air condensate

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