CLINICAL AND BIOCHEMICAL PREDICTORS IN PATIENTS WITH OBESITY AND NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS

DOI: https://doi.org/10.29296/25877313-2019-05-06
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Issue: 
5
Year: 
2019

N.P. Mikaelyan Dr.Sc. (Biol.), Professor, Department of Biochemistry and Molecular Biology, Medical Faculty, Pirogov Russian National Research Medical University (Moscow) E-mail: ninmik@yandex.ru P.A. Skripkina Ph.D. (Med.), Associate Professor, Department of Dermatovenerology, Medical Faculty, Pirogov Russian National Research Medical University (Moscow) T.A. Gaidina Ph.D. (Med.), Associate Professor, Department of Dermatovenerology, Medical Faculty, Pirogov Russian National Research Medical University (Moscow) A.V. Mikaelyan Ph.D. (Med.), Associate Professor, Department of Obstetrics and Gynecology, Faculty of Advanced Training of Doctors, Moscow regional Clinical Research Institute. M.F. Vladimirsky (Moscow)

The aim of the study was to study some clinical and metabolic parameters in patients with insulin resistance in obesity and newly diagnosed type 2 diabetes mellitus. In 57 women aged 23 to 39 years with obesity 3-4 degrees and the first identified type 2 diabetes mellitus, the lipid composition of the erythrocyte membranes and the state of lipid peroxidation and antioxidant activity were studied. The control group consisted of 15 women without endocrine pathology. The study of biochemical predictors in patients with newly diagnosed diabetes mellitus type 2 and in patients with obesity, along with dyslipidemia, showed a violation of the composition of fatty acids in the blood due to the group of omega-3 and omega-6. Increased intensity lipid peroxidation on the background of reduced activity of antioxidants and the level of omega-3 fatty acids indicates the development of oxidative stress, the most pronounced in type 2 diabetes compared to obesity. The results of the study also indicate the presence of the antioxidant properties of omega-3 fatty acids, as evidenced by the direct correlation between omega-3 fatty acids and the activity of antioxidant enzymes. Conclusion: 1. In patients with diabetes mellitus type 2 and in patients with obesity, dyslipidemia, a violation of the composition of fatty acids are noted. 2. The development of oxidative stress, most pronounced in type 2 diabetes mellitus, was established. 3. Direct correlation relationships between omega-3 fatty acids and the activity of the studied enzymes indicate the presence of the antioxidant properties of omega-3 fatty acids.

Keywords: 
diabetes mellitus
fatty acids
oxidative stress
insulin resistance

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