INCREASE IN THE ANTICONVULSANT EFFICACY OF MIDAZOLAM DURING ITS MICROENCAPSULATION

DOI: https://doi.org/10.29296/25877313-2019-06-08
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Issue: 
6
Year: 
2019

M.A. Judin Dr.Sc. (Med.), Associate Professor, State Research Test Institute of Military Medicine of the Russian Federation Defense Ministry (St. Petersburg) S.V. Chepur Dr.Sc. (Med.), Professor, State Research Test Institute of Military Medicine of the Russian Federation Defense Ministry (St. Petersburg) A.F. Bykova Ph.D. ( Biol.), State Research Test Institute of Military Medicine of the Russian Federation Defense Ministry (St. Petersburg) E-mail: anna-kurpyakova@rambler.ru M.S. Vahviayanen Laboratorian, State Research Test Institute of Military Medicine of the Russian Federation Defense Ministry (St. Petersburg) S.N. Subbotina Ph.D. (Biol.), State Research Test Institute of Military Medicine of the Russian Federation Defense Ministry (St. Petersburg)

Purpose of the study. A comparative study of the anticonvulsant activity of microencapsulated forms of midazolame on the model of pentilenetetrazol seizures. Materials and methods. Anticonvulsant activity of midazolam and microencapsulated samples of midazolam based on alginate and polylactide-co-glicolide was evaluated on white outbred male mice on a model of convulsive syndrome caused by the intramuscular administration of pentylenetetrazole at a dose of 1 LD99. Results. It has been established that the inclusion of midazolam in polymer particles based on sodium alginate with a ratio of midazolam and polymer 1:9 contributes to an increase in the duration of the anticonvulsant effect and the protective action of prophylactic administration 5-30 minutes before poisoning. Findings. The advantage of sodium alginate-based polymer particles over polylactide-co-glicolide-based particles with respect to the anticonvulsant and protective efficacy of midazolam in experiments on mice is shown.

Keywords: 
midazolam
microencapsulation
prolonged form
anticonvulsant action
pentylenetetrazole

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