PHARMACOLOGICAL EFFICACY FERULOPSIS HYSTRIX (BUNGE) PIMENOV OF DRY EXTRACT IN EXPERIMENTAL OF INDOMETHACIN-INDUCED GASTROPATHY

The purpose of the study was to evaluate the gastroprotective effect of dry extract from the roots and rhizomes of Ferulopsis hystrix (Bunge) Pimenov in indomethacin-induced gastropathy. Materials and methods. The studies were carried out on white Wistar rats. The indomethacin-induced gastropathy was simulated by a single intra-gastric administration of indomethacin in dose of 60 mg/kg. The F. hystrix dry extract in the doses 100 and 200 mg/kg was administered to animals I and II experimental groups for 7 days before the modeling of gastropathy. Animals of the III experimental groups were received the preparation of comparison – plantaglucid in the 300 mg/kg. The gastroprotective effect of F. hystrix was estimated taking into account the Pauls’ index which was calculated for erosions and strip-like ulcers as well as taking into account the morphometric indices (the depth of erosions) of the stomach mucosa. Results. The F. hystrix dry extract in the dose of 200 mg/kg was decreased the average number of erosions and stripe-like ulcers by 2 (p≤ 0.05) and 5 (p≤ 0.05) times and the Pauls’ index – by 2 and 20 times respectively as compared to the control. The F. hystrix extract in the doses of 100 and 200 mg/kg was reduced the depth of erosions by 35% and 74% respectively as compared to the control. Conclusion. Thus, F. hystrix has the gastroprotective effect in indomethacin-induced gastropathy. The F. hystrix dry extract in the dose of 200 mg/kg manifests the gastroprotective effect surpassing the effect of the preparation of comparison – plantaglucide.