PHARMACOLOGICAL EFFICACY FERULOPSIS HYSTRIX (BUNGE) PIMENOV OF DRY EXTRACT IN EXPERIMENTAL OF INDOMETHACIN-INDUCED GASTROPATHY

DOI: https://doi.org/10.29296/25877313-2019-08-06
Issue: 
8
Year: 
2019

S.M. Salchak Post-graduate Student, Institute of General and Experimental Biology SB RAS (Ulan-Ude); Research Scientist, Department of Organology, Spa Care and Folk Medicine, Research Institute of medico-social problems and management of the Tyva Republic (Kyzyl) E-mail: saizana_salchak@mail.ru Ya.G. Razuvaeva Dr.Sc. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude) K.D. Arakchaa Ph.D. (Chem.), Director, Research Institute of medical and social problems and management of the Republic of Tuva (Kyzyl) A.A. Toropova Ph.D. (Biol.), Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude) D.N. Olennikov Dr.Sc. (Pharm.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude)

The purpose of the study was to evaluate the gastroprotective effect of dry extract from the roots and rhizomes of Ferulopsis hystrix (Bunge) Pimenov in indomethacin-induced gastropathy. Materials and methods. The studies were carried out on white Wistar rats. The indomethacin-induced gastropathy was simulated by a single intra-gastric administration of indomethacin in dose of 60 mg/kg. The F. hystrix dry extract in the doses 100 and 200 mg/kg was administered to animals I and II experimental groups for 7 days before the modeling of gastropathy. Animals of the III experimental groups were received the preparation of comparison – plantaglucid in the 300 mg/kg. The gastroprotective effect of F. hystrix was estimated taking into account the Pauls’ index which was calculated for erosions and strip-like ulcers as well as taking into account the morphometric indices (the depth of erosions) of the stomach mucosa. Results. The F. hystrix dry extract in the dose of 200 mg/kg was decreased the average number of erosions and stripe-like ulcers by 2 (p≤ 0.05) and 5 (p≤ 0.05) times and the Pauls’ index – by 2 and 20 times respectively as compared to the control. The F. hystrix extract in the doses of 100 and 200 mg/kg was reduced the depth of erosions by 35% and 74% respectively as compared to the control. Conclusion. Thus, F. hystrix has the gastroprotective effect in indomethacin-induced gastropathy. The F. hystrix dry extract in the dose of 200 mg/kg manifests the gastroprotective effect surpassing the effect of the preparation of comparison – plantaglucide.

Keywords: 
Ferulopsis hystrix (Bunge) Pimenov
gastroprotective effect
indomethacin-induced gastropathy

References: 
  1. Martynova N.A. K voprosu o profilaktike NPVP-associirovannoi gastroenteropatii // Medicina v Kuzbasse. 2016. T.15. № 4. S. 21-23.
  2. Aksinenko S.G., Suslov N.I., Kravcova S.S. Issledovanie protivoyazvennoj aktivnosti izvlechenij iz list'ev ivy korzinchatoj // Eksperimental'naya i klinicheskaya gastroenterologiya. 2012. № 1. S. 79-83.
  3. Kurmanova Е.N. Trumpe T.Е., Ferubko Е.V. Protivoyazvennoe dejstvie ekstrakta volodushki // Voprosy obespecheniya kachestva lekarstvennyh sredstv. 2018. T.4. № 22. S. 4-8.
  4. Athaydes B.R., Alves G.M., Monteiro de Assis A.L.E., Gomes J.V.D., Rodrigues R.P., Campagnaro B.P., Nogueira B.V., Silveira D., Kuster R.M., Pereira T.M.C., Kitagawa R.R., Gonçalves R.C.R. Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice // Food Research International. 2019. Vol. 119. Р. 751-760.
  5. Morshedi M., Gol А., Mohammadzadeh А. The effect of Matricaria chamomilla on the treatment of ibuprofen-induced gastric ulcers in male rats // Hormozgan Medical Journal. 2016. V. 20. № 4. Р. 270-275.
  6. Rastitel'nye resursy: Dikorastushchie svetkovye rasteniya, ih komponentnyi sostav i biologicheskaya aktivnost'. T.3. Semeistvo Fabaceae – Apiaceae / Otv. red. A.L. Budancev / SPb; M., 2010. 601 s.
  7. Taraskin V.V., Radnaeva L.D., Zhigzhitzhapova S.V., Anenhonov O.A., Ganbaatar Zh. Sravnitel'nyi analiz sostava efirnogo masla Phlojodicarpus turczaninovii sipl. (Aplaceae), proizrastayushchego v Mongolii i Buryatii // Vestnik Buryatskogo gosudarstvennogo universiteta. 2011. Vyp. 3. S. 111-115.
  8. Barot K.P., Jain S.V., Kremer L., Singh S., Manjunath D.G. Recent advances and therapeutic journey of coumarins: current status and perspectives // Medicinal Chemistry Researsh. 2015. № 24. P. 2771-2798.
  9. Mashkovskij M.D. Lekarstvennye sredstva. M., 2012. 1216 s.
  10. Ubeeva I.P., Nikolaev S.M., Verlan N.V. Fitoterapiya zabolevanij zheludka. Irkutsk, 2009. 92 s.
  11. Baginskaya A.I., Ferubko E.V., Kurmanova E.N. i dr. Experimental'nye modeli erozivno-yazvennyh porazhenii zheludka i dvenadsatiperstnoi kishki/ M.:«Izdatel'skii dom «Russkii vrach». 2017; 96 s.
  12. Potapova A.A., Dorkina E.G., Sergeeva E.O. i dr. Izuchenie membranostabiliziruyushchego i antioksidantnogo deistviya baikalina // Sovremennaya nauka i innovacii. 2016. № 1. S. 148-152.
  13. Grover J., Jachak S.M. Coumarins as privileged scaffold for anti-inflammatory drug development // The Royal Society of Chemistry. 2015. № 5.
  14. P. 38892-38905.
  15. Taraskin V.V., Radnaeva L.D.,Shults E.E., Ganbaatar Zh., Nikolaeva I.G. Vydelenie rabochego standartnogo obrazsa peucenidina – angulyarnogo furokumarina zontichnyh flory Buryatii i Mongolii // Ekologobezopasnye i resursosberegayushchie tehnologii i materially. Ulan-Ude, 2014. S. 231-232.
  16. Shahmardanova S.A., Gulevskaya O.N., Seleckaya V.V. Antioksidanty: klassifikaciya, farmakoterapevticheskie svojstva, ispol'zovanie v prakticheskoj medicine // Zhurnal fundamental'noj mediciny i biologii. 2016. № 3. S. 4-15.