EVALUATION OF ANTI-INFLAMMATORY AND GASTROPROTECTIVE PROPERTIES OF EXTRACTS OF MOLDAVIAN DRAGONHEAD

DOI: https://doi.org/10.29296/25877313-2019-09-09
Issue: 
9
Year: 
2019

E.N. Kurmanova Research Scientist, Department of Experimental and Clinical Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: kurmanova1968@yandex.ru E.V. Ferubko Ph.D. (Med.), Head of the Department of Experimental and Clinical Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) O.P. Sheichenko Ph.D. (Chem.), Leading Research Scientist, Department of Phytochemistry and Standardization, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow)

In VILAR developed Moldavian dragonhead herb extract dry Lyukatil. The study of the effect of the extract Lyukatil on the course of exudative phase of inflammation in mice and the condition of the gastric mucosa of rats in acute experimental ulcers using the ethanol model. It was found that the extract at a dose of 200 mg/kg with a three-day administration has a significant anti-inflammatory effect, suppressing the development of the ex-udative phase of inflammation caused by formalin by 33.7%, compared with the control group of animals. In terms of ethanol, the experimental mod-els of gastric ulcers when administered extract at a dose of 100 mg/kg, significant gastroprotective effect – the reduction in area of ulcers by 23.5%. With an increase in the dose of the extract to 200 mg/kg, the area of ulcerative defects was reduced by 86.16%. The results of these studies, the au-thors found that Lyukatil is a promising target for further pharmacological examination.

Keywords: 
extract of Moldavian dragonhead
anti-inflammatory activity
gastroprotective activity

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