Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

EFFICIENCY OF MAGNESIUM OROTATE ON COLLAGEN EXCHANGE AND CONTENT OF MINERAL COMPONENTS IN BONE TISSUE OF RATS WITH STEROID OSTEOPOROSIS

DOI: https://doi.org/10.29296/25877313-2019-11-08
Download full text PDF
Issue: 
11
Year: 
2019

Authors, 2019 N.V. Savinova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) E-mail: biochem2017@.mail.ru O.V. Danilova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) N.G. Naumova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) S.E. Perevedentseva Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) S.R. Trofimova Ph.D. (Biol.), Izhevsk State Medical Academy (Izhevsk)

The aim of the study. To evaluate the efficiency of Magnerot medication on the collagen exchange and the mineral component of bone tis-sue in rats with glucocorticoid osteoporosis. Materials and Methods. Magnerot was being introduced intragastrically to the animals with steroid os-teoporosis for 10 days. The amount of total collagen, neutral salt soluble collagen and free hydroxyproline in the diaphysis of the femur and the body of the second lumbar vertebra of rats were determined by colorimetry. Calcium, magnesium and phosphorus content in the bone tissue and blood plas-ma was revealed by atomic emission spectroscopy with inductively bound plasma. Results. In the bone tissue of animals with osteoporosis which received Magnerot were noted: elevation of concentration of neutral salt soluble collagen, reduction of the level of free hydroxyproline and increase of the content of total collagen and the components of mineral phase (calcium, phosphorus, magnesium). Conclusion. Administration of Magnerot to animals with glucocorticoid osteoporosis promotes the activation of synthesis and inhibition of collagen decay, as well as corrects the changes in the content of mineral components in the bone tissue. The results of our research testify to promising use of Magnerot as a part of complex therapy of os-teoporosis to promote remodulation of bone tissue.
Keywords: 
osteoporosis
glucocorticoids
collagen
mineral matrix
magnesium orotate
phosphatidylserine

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Toropcova N.V. Gljukokortikoidnyj osteoporoz: diagnostika, profilaktika i lechenie // Nauchno-prakticheskaja revmatologija. 2014; 4: 423–429.
  2. Gromova O.A., Torshin I.Ju., Jurgel' I.S. Retrospektiva farmakokineticheskih issledovanij magnievyh preparatov // Trudnyj pacient. 2009; 6: 44–8.
  3. Ziganshina L.E., Burnasheva Z.A., Valeeva I.H. Sravnitel'noe izuchenie jeffektivnosti dimefosfona i ksidofona pri steroidnom osteoporoze u krys // Jeksperimental'naja i klinicheskaja farmakologija. 2000; 6: 39–42.
  4. Sharaev P.N., Butolin E.G., Ivanov V.G. Pokazateli obmena biopolimerov soedinitel'noj tkani pri mnogo¬kratnom stresse // Ukrainskij biohimicheskij zhurnal. 1987; 3: 85.
  5. Proshina L.Ja., Privalenko M.N. Issledovanie frakcionnogo sostava kollagena v tkani pecheni // Voprosy medicinskoj himii. 1982; 1: 115–119.
  6. Ivanov S.I., PodunovaL.G., V.B.Skachkov V.B., Tutel'jan V.A., Skal'nyj A.V., Demidov V.A., Skal'naja M.G., Serebrjanskij E.P., Grabeklis A.R., Kuznecov V.V. Opredelenie soderzhanija himicheskih jelementov v diagnostiruemyh biosubstratah, polivitaminnyh preparatah s mikrojelementami, v biologicheski aktivnyh dobavkah k pishhe i v syr'e dlja ih izgotovlenija metodom atomnoj jemissionnoj spektrometrii s induktivno svjazannoj argonovoj plazmoj: Metodicheskie ukazanija (MUK 4.1.1482-03). M.: Federal'nyj Centr Gossanjepidnadzora Minzdrava Rossii. 2003; 56 s.
  7. Blaine J., Chonchol M., Levi M. Renal control of calcium, phosphate, аnd magnesium homeostasis // Clin J Am Soc Nephrol. 2015; 10:1257–1272
  8. Muhammad V. M., Singh R., Malhotra R. Mineral transporters – the novel approach in management of bone health and osteoporosis // Orthopedics today. 2010; 12: 1–6.
  9. He L.Y., Zhang X.M., Liu B. et al. Effect of magnesium ion on human osteoblast activity // Braz J Med Biol Res. 2016; 49: 52-7.
  10. Torshin I.Ju., Gromova O.A. Displazii soedinitel'noj tkani, kletochnaja biologija i molekuljarnye mehanizmy vozdejstvija magnija // Russkij medicinskij zhurnal. 2008; 4:230–238.
  11. Rude R.K., Singer F.R., Gruber H.E. Skeletal and hormonal effects of magnesium deficiency // J. Am. Coll. Nutr. 2009; 28:131–141.
  12. Nemcova M.V., Bykov I.I., Chekunova N.V., Zaletaev D.V., Gluhov A.I., Horobryh T.V. Sistemy molekulyarno-geneticheskih markerov pri rake zheludka // Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2013. № 10. S. 6772.
  13. Westphal О., Jann K. Bacterial lipopolysaccharides. Extraktion with phenol-water and further applications of the procedure // Methods Carbohydr. Chem. 1965. № 5. P. 8391.
  14. Zaharova I.Ya., Varbanec L.D. Uglevodsoderzhashchie biopolimery membran bakterij. Kiev: Nauk. dumka, 1983. 128 s.
  15. Ploskonos M.V., Nikolaev A.A. Sposob vydeleniya lipopolisaharida Chlamydia trachomatis. Patent RF № 2593946 ot 13.04.2015.
  16. WHO laboratory manual for the examination and processing of human semen. 2010. 5th ed. WHO (Geneva).