EFFICIENCY OF MAGNESIUM OROTATE ON COLLAGEN EXCHANGE AND CONTENT OF MINERAL COMPONENTS IN BONE TISSUE OF RATS WITH STEROID OSTEOPOROSIS

DOI: https://doi.org/10.29296/25877313-2019-11-08
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Issue: 
11
Year: 
2019

Authors, 2019 N.V. Savinova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) E-mail: biochem2017@.mail.ru O.V. Danilova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) N.G. Naumova Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) S.E. Perevedentseva Ph.D. (Med.), Izhevsk State Medical Academy (Izhevsk) S.R. Trofimova Ph.D. (Biol.), Izhevsk State Medical Academy (Izhevsk)

The aim of the study. To evaluate the efficiency of Magnerot medication on the collagen exchange and the mineral component of bone tis-sue in rats with glucocorticoid osteoporosis. Materials and Methods. Magnerot was being introduced intragastrically to the animals with steroid os-teoporosis for 10 days. The amount of total collagen, neutral salt soluble collagen and free hydroxyproline in the diaphysis of the femur and the body of the second lumbar vertebra of rats were determined by colorimetry. Calcium, magnesium and phosphorus content in the bone tissue and blood plas-ma was revealed by atomic emission spectroscopy with inductively bound plasma. Results. In the bone tissue of animals with osteoporosis which received Magnerot were noted: elevation of concentration of neutral salt soluble collagen, reduction of the level of free hydroxyproline and increase of the content of total collagen and the components of mineral phase (calcium, phosphorus, magnesium). Conclusion. Administration of Magnerot to animals with glucocorticoid osteoporosis promotes the activation of synthesis and inhibition of collagen decay, as well as corrects the changes in the content of mineral components in the bone tissue. The results of our research testify to promising use of Magnerot as a part of complex therapy of os-teoporosis to promote remodulation of bone tissue.

Keywords: 
osteoporosis
glucocorticoids
collagen
mineral matrix
magnesium orotate
phosphatidylserine

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