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THE DIFFERENTIAL SCANNING CALORIMETRY OF BINARY SYSTEMS WITH PARTICIPATION OF SOME ANTIFUNGAL SUBSTANCES; ANTIFUNGAL ACTIVITY OF EUTECTIC STRUCTURES
DOI: https://doi.org/10.29296/25877313-2020-05-03
Issue:
5
Year:
2020
The parameters of the invariant equilibrium points of binary systems (for a total of 19 pairs of substances) of some antimycotic substances obtained using differential scanning calorimetry and the results of preclinical testing of eutectic dispersions with respect to N. Candida albicans (ATCC 90028) and a culture resistant to antifungal azoles are presented R. Candida albicans isolated from clinical material. The belonging of the investigated binary sys-tems to simple eutectics is established. It was found that the antifungal activity of eutectic dispersions is significantly higher than the activities of the initial components from 4 to 4 thousand times both in relation to the N. Candida albicans and in relation to its resistant form. The noted features may be useful in the clinical use of eutectic dispersions of antifungal substances as an antifungal drug delivery system for more effective achievement of therapeutic goals.
Keywords:
Differential scanning calorimetry
phase equilibria
eutectic
antifungal activity
resistance
eutectic drug delivery system
References:
- Tkachenko M.L., Zhnyakina L.E., LyaminA.V. Antigribkovaya kompoziciya evtecticheskogo tipa (variant). Patent na izobretenie. № 2674765(RF). 2018.
- Fiala Sarah, Jonesa Stuart A., Brown Marc B. A fundamental investigation into the effects of eutectic formation on transmembrane transport. International Journal of Pharmaceutics. 2010; 393: 68–73.
- Bonain A. Note au sujet de l’anesthesique local employéenoto-rhinolaryngologie sous la domination liquide de Bonain. Ann Malad Oreille Larynx. 1907; 33; 216–217.
- Zalcin V.M. O sovremennom sostoyanii teorii evtectic. Zhurn. fiz. himii. 1984; 58: 1320.
- Petrov V.S., Miheikin I.D., Mahonina E.V., Buckii V.D. Supramolecularnye ansambli vevtecticheskih splavah. Uspehihimii. 2003; 72(9):852–863.
- Moshchenskij Yu.V. Differencial’nyj skaniruyushchij kalorimetr DSK-500. Pribory i tehnika eksperimenta. 2003; 6:143–144.
- Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv. Chast' pervaya. Pod red. A.N. Mironova. M.: «Grifi K». 2012.
- Anosov V.Ya., Ozerova M.I., Fialkov Yu.Ya. Osnovy fiziko-himicheskogo analiza. M.: Nauka. 1976. S. 125–127.