THE DIFFERENTIAL SCANNING CALORIMETRY OF BINARY SYSTEMS WITH PARTICIPATION OF SOME ANTIFUNGAL SUBSTANCES; ANTIFUNGAL ACTIVITY OF EUTECTIC STRUCTURES

DOI: https://doi.org/10.29296/25877313-2020-05-03
Issue: 
5
Year: 
2020

A.N. Seryakova Assistant, Department of Chemistry of Pharmaceutical Faculty, Samara State Medical University (Samara) E-mail: seryakova_annet@mail.ru M.L. Tkachenko Ph.D. (Chem.), Associate Professor, Department of Chemistry of Pharmaceutical Faculty, Samara State Medical University (Samara) E-mail: tka-mikhail@yandex.ru A.V. Lyamin Ph.D. (Med.), Associate Professor, Department of General and Clinical Microbiology, Immunology and Allergology, Samara State Medical University (Samara) E-mail: avlyamin@rambler.ru L.E. Zhnyakina Dr.Sc. (Pharm.), Pharmacist-Analyst, SFHI «Center of Quality Control of Drags of the Samara Region» (Samara) E-mail: si5w1245@yandex.ru

The parameters of the invariant equilibrium points of binary systems (for a total of 19 pairs of substances) of some antimycotic substances obtained using differential scanning calorimetry and the results of preclinical testing of eutectic dispersions with respect to N. Candida albicans (ATCC 90028) and a culture resistant to antifungal azoles are presented R. Candida albicans isolated from clinical material. The belonging of the investigated binary sys-tems to simple eutectics is established. It was found that the antifungal activity of eutectic dispersions is significantly higher than the activities of the initial components from 4 to 4 thousand times both in relation to the N. Candida albicans and in relation to its resistant form. The noted features may be useful in the clinical use of eutectic dispersions of antifungal substances as an antifungal drug delivery system for more effective achievement of therapeutic goals.

Keywords: 
Differential scanning calorimetry
phase equilibria
eutectic
antifungal activity
resistance
eutectic drug delivery system

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