Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

METABOLIC CORRECTION OF ANTIOXIDANT STATUS OF BLOOD USING OMEGA-3 POLYUNSATURATED FATTY ACIDS IN THE TREATMENT OF PSORIASIS PATIENTS

DOI: https://doi.org/10.29296/25877313-2020-07-09
Download full text PDF
Issue: 
7
Year: 
2020

L.B. Gaykovaya Dr.Sc. (Med.), Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: largaykovaya@yandex.ru N.V. Tyunina Post-graduate Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: nadintv15@gmail.com R.N. Pavlova Ph.D. (Med.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: RNP.apr2020@yandex.ru A.T. Burbello Dr.Sc. (Med.), Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: at-burbello@yandex.ru J.V. Antonova Ph.D. (Biol.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: antonova.janna2016@yandex.ru L.A. Karyakina Ph.D. (Med.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: doca_kla@mail.ru I.S. Kustov Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru N.S. Boyko Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru K.S. Lysenko Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru

Relevance. Psoriasis is considered as a multifactorial chronic, inflammatory, immuno-dependent recurrent disease, accompanied by an increased level of skin cell proliferation. One of the factors contributing to the start of proliferation processes is a decrease in the intensity of free radical oxidation processes. Objective. To study the effect of omega-3 PUFAs on the state of the antioxidant blood system and the resistance of superoxide dismutase (SOD) to the action of oxidizing agents in patients with psoriasis. Results. It has been established that in patients with psoriasis there is a shift in the redox state in the direction of increasing restored equivalents due to an increase in the total HS groups of blood plasma, the ratio between catalase and superoxide dismutase, and also a decrease in the sensitivity of superoxide dismutase to oxidizing agents. It has been shown that in patients with psoriasis, when omega-3 polyunsaturated fatty acids are added to the standard therapy at a dose of 3450 mg / day, the content of blood plasma HS groups is significantly increased, and the sensitivity of superoxide dismutase to the action of the oxidizing agent is restored. Conclusions. The use of "Omega-3 35%" in patients with psoriasis for a month led to the formation of a tendency to normalize the response of SOD to the oxidizing agent. The ratio of CAT / SOD and the content of protein and non-protein HS blood groups can be used to assess the effectiveness of omega-3 PUFAs as antioxidant correction drugs for psoriasis.
Keywords: 
psoriasis
omega-3 polyunsaturated fatty acids
antioxidant system
SOD resistance to oxidizing agents

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Pritulo O.A., Rychkova I.V. Sovremennye predstavlenija o patogeneze psoriaza. Tavricheskij mediko-biologicheskij vestnik. 2017; 20(1): 141–153.
  2. Shilov V.N., Sergienko V.N. Novye podhody k izucheniju patogeneza i lechenija psoriaza. Bjullet-en' jeksperimental'noj biologii i mediciny. 2000; 129(4): 364–369.
  3. Grashin R.A., Antonov V.G., Karpishhenko A.I. Sistemy svobodnoradikal'nogo okislenija i anti-oksidantnoj zashhity kak indikatory aktivnosti proliferacii keratinocitov pri psoriaze. Klinicheskaja la-boratornaja diagnostika. 2010; 1: 18–24.
  4. Tarasenko G.N., Hyshitkuev B.S., Kornilov A.B. Osobennosti zhirnokislotnogo spektra jepider-misa u bol'nyh psoriazom. Voennyj medicinskij zhurnal. 2002; 2: 61–62.
  5. Pavlova R.N., Karjakina L.A., Bejshebaeva Ch.R. Dadali V.A. Issledovanie sostojanija antioksi-dantnoj sistemy pri ispol'zovanii omegalicina kak preparata korrekcii pri lechenii bol'nyh psoriazom. Vo-prosy biologicheskoj mediciny i farmacevticheskoj himii. 2013; 4: 69–72.
  6. Gajkovaja L.B., Pavlova R.N., Burbello A.T., Tjunina N.V., Antonova Zh.V., Sokolova M.N., Karjakina L.A., Murzina A.A. Sravnenie odnorazovogo i trehkratnogo priema poliena, kak preparata korrekcii pri lechenii bol'nyh psoriazom. Materialy VI Mezhdunar. nauchno-prakt. konf. «Aktual'nye vo-prosy mediciny v sovremennyh uslovijah». 2019. S.46.
  7. Omega-3 polinenasyshhennye zhirnye kisloty v jeksperimente i klinicheskoj praktike. Pod red. A.T. Burbello, L.B. Gajkovoj, G.A. Kuharchik. SPb: 2017. 370 s.
  8. Nekipelova A.V., Kulinenko Zh.G., Jakubovich A.I., Saldamaeva L.S. Nutricevtivnaja podderzhka bol'nyh psoriazom s primeneniem polinenasyshhennyh zhirnyh kislot omega-3. Sibirskij medicinskij zhurnal (Irkutsk). 2015; 5: 81–85.
  9. Gajkovaja L.B. Omega-3 polinenasyshhennye zhirnye kisloty: laboratornye metody v ocenke ih mnogofaktornogo dejstvija. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. 2010; 6(4): 3–14.
  10. Gajkovaja L.B., Pavlova R.N., Tjunina N.V., Antonova Zh.V, Bejshebaeva Ch.R., Smertina M.N., Karjakina L.A, Kukushkina K.S. Sravnenie preparatov okeanola, poliena i omakora po dejstviju na sostojanie antioksidantnoj sistemy krovi bol'nyh psoriazom v opytah «in vitro». Profilakticheskaja i klinicheskaja medicina. 2017; 4(65): 48–55.
  11. Arutjunjan A.V., Dubinina E.E., Zybina N.N. Metody ocenki svobodnoradikal'nogo okislenija i antioksidantnoj sistemy. SPb. 2000. 67 s.
  12. Putilina F.E., Galkina O.V., Eschenko N.D. Svobodnoradikalnoe okislenie. Pod red. N.D. Eschen-ko. SPb: Izd-vo un-ta. 2008. 161 s.
  13. Garkavi L.H., Kvakina E.B., Kuzmenko T.S. Antistressornyie reaktsii i aktivatsionnaya terapiya. M.: YoYo Media. 2012. 559 s.
  14. Goncharova L.L. Tioldisulfidnaya sistema v klinicheskoy praktike. Laboratornaya diagnostika – Terra medica. 2003; 2: 3–6.
  15. Sokolovskij V.V. Tioldisul'fidnaja sistema v reakcijah organizma na faktory okruzhajushhej sredy. Sankt-Peterburg. Nauka 2008. 118 s.
  16. Hansen R., Roth D., Winther J. Quantifying the global cellular thiol-disulfide status. Proc. Natl. Acad/ Sci. USA, 2009; 106(2): 422–427.
  17. Go Y. Jonts D. Tioldisulfide redox states in signaling and sensing. Crit. rev. biochem. mol. Biol. 2013; 48(2): 173–181.
  18. Pimentel D., Haeussler D.J., Matsui R., Burgoyne J.R., Cohen R.A., Bachschmid M.M.l. Regula-tion of Cell Physiology and Pathology by Protein
  19. S-glutathionylation: Lessons Learned From the Cardiovascular System. Antioxid Redox Signal. 2012 Mar 15;16(6):524-42. doi: 10.1089/ars.2011.4336.