METABOLIC CORRECTION OF ANTIOXIDANT STATUS OF BLOOD USING OMEGA-3 POLYUNSATURATED FATTY ACIDS IN THE TREATMENT OF PSORIASIS PATIENTS

DOI: https://doi.org/10.29296/25877313-2020-07-09
Issue: 
7
Year: 
2020

L.B. Gaykovaya Dr.Sc. (Med.), Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: largaykovaya@yandex.ru N.V. Tyunina Post-graduate Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: nadintv15@gmail.com R.N. Pavlova Ph.D. (Med.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: RNP.apr2020@yandex.ru A.T. Burbello Dr.Sc. (Med.), Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: at-burbello@yandex.ru J.V. Antonova Ph.D. (Biol.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: antonova.janna2016@yandex.ru L.A. Karyakina Ph.D. (Med.), Associate Professor, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: doca_kla@mail.ru I.S. Kustov Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru N.S. Boyko Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru K.S. Lysenko Student, North-Western State Medical University after I.I. Mechnikov under the Ministry of Public Health of the Russian Federation (Saint-Petersburg) E-mail: biochem5@yandex.ru

Relevance. Psoriasis is considered as a multifactorial chronic, inflammatory, immuno-dependent recurrent disease, accompanied by an increased level of skin cell proliferation. One of the factors contributing to the start of proliferation processes is a decrease in the intensity of free radical oxidation processes. Objective. To study the effect of omega-3 PUFAs on the state of the antioxidant blood system and the resistance of superoxide dismutase (SOD) to the action of oxidizing agents in patients with psoriasis. Results. It has been established that in patients with psoriasis there is a shift in the redox state in the direction of increasing restored equivalents due to an increase in the total HS groups of blood plasma, the ratio between catalase and superoxide dismutase, and also a decrease in the sensitivity of superoxide dismutase to oxidizing agents. It has been shown that in patients with psoriasis, when omega-3 polyunsaturated fatty acids are added to the standard therapy at a dose of 3450 mg / day, the content of blood plasma HS groups is significantly increased, and the sensitivity of superoxide dismutase to the action of the oxidizing agent is restored. Conclusions. The use of "Omega-3 35%" in patients with psoriasis for a month led to the formation of a tendency to normalize the response of SOD to the oxidizing agent. The ratio of CAT / SOD and the content of protein and non-protein HS blood groups can be used to assess the effectiveness of omega-3 PUFAs as antioxidant correction drugs for psoriasis.

Keywords: 
psoriasis
omega-3 polyunsaturated fatty acids
antioxidant system
SOD resistance to oxidizing agents

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