FUNCTIONAL ACTIVITY OF ALBUMIN AND HEMOSTASIS DISORDERS IN CANCER PATIENTS WITH PURULENT SEPTIC COMPLICATIONS

DOI: https://doi.org/10.29296/25877313-2020-10-03
Issue: 
10
Year: 
2020

О.V. Somonova Dr.Sci. (Med.), Senior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) E-mail: somonova@mail.ru А.L. Elizarova Ph.D. (Biol.), Senior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) Т.V. Davydova Ph.D. (Biol.), Head of Laboratory of Clinical Diagnostic, N.N. Blokhin National Medical Research Center of Oncology (Moscow) А.V. Сytov Ph.D. (Med.), Head of Department of Anesthesiology and Reanimatology, N.N. Blokhin National Medical Research Center of Oncology (Moscow) N.N. Borisenko Junior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) U.А. Kornyushenko Junior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) Е.G. Golovnya Junior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) J.А. Nesterova Junior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow) М.М. Dobrovolskaya Ph.D. (Biol.), Junior Research Scientist, N.N. Blokhin National Medical Research Center of Oncology (Moscow

The development of purulent-septic complications in cancer patients after surgery complicates the course of the postoperative period. One of the ways to solve the problem is to search for markers that make it possible to diagnose as early as possible, evaluate treatment and predict the outcome of infectious complications. Preliminary studies have shown abnormalities in the detoxification function of serum albumin in cancer patients as a prog-nostic marker of the occurrence of purulent-septic complications in the postoperative period. In addition, purulent-septic complications are one of the most frequent causes of disorders in the hemostatic system, from isolated thrombocytopenia to acute disseminated intravascular coagulation, which complicate the course of the postoperative period. The aim of this work is to assess the diagnostic significance of indicators of the functional activity of albumin, biomarkers of sepsis and the state of the hemostasis system in cancer patients with purulent-septic complications. The studies have shown that the indicator of the detoxification efficiency of serum albumin, determined already on the first day of the development of septic complications and in dynamics within 20 days after the operation, is a laboratory indicator of the prognosis of the course of these complications in cancer patients. In cancer patients, a significant increase in presepsin (an early marker of sepsis) is observed already from the first day of the de-velopment of purulent-septic complications (up to 1986 pg/m) and after 12 days procalcitonin rises (up to 112 ng/ml). A significant activation of blood coagulation and the development of various forms of DIC syndrome with the consumption of natural thrombin inhibitors, fibrinolysis components and platelets must be taken into account in the complex therapy of septic conditions. The results of evaluating the effectiveness of the detoxification activity of albumin, the level of presepsin and procalcitonin, the assessment of the intensity of intravascular blood coagulation can be used to accompany cancer patients during surgical treatment and timely detection of purulent-septic complications, which significantly aggravate the course of the postoperative period, lengthen the time of hospital stay and increase the cost of treatment.

Keywords: 
functional activity of albumin
hemostasis system
purulent-septic complications
oncology

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