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EVALUATION OF THE EFFECTIVENESS OF METABOLIC THERAPY IN THE TREATMENT OF DIABETIC POLYNEUROPATHIES IN PATIENTS WITH TYPE 2 DIABETES

DOI: https://doi.org/10.29296/25877313-2020-10-04
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Issue: 
10
Year: 
2020

I.N. Pashkova assistant of the Department of pharmacology and pharmaceutical consulting with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) T.V. Potupchik Ph.D. (Medical), Associate Professor, Department of pharmacology and pharmaceutical consulting with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) I.V. Gackich Ph.D. (Medical), Associate Professor, Department of pharmacology and pharmaceutical consulting with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) M.M. Petrova Dr.Sc. (Medical), Professor, first Vice-rector, Head of the Department of outpatient therapy and family medicine with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) O.F. Veselova Associate Professor, Head of the Department of pharmacology and pharmaceutical consulting with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) A.N. Narkevich Ph.D. (Medical), Associate Professor, Head of the Department of medical Cybernetics and Informatics, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk) T.P. Shalda Senior Lecturer, Department of pharmacology and pharmaceutical consulting with a postgraduate course, Federal state budgetary educational institution of higher education "Krasnoyarsk state medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of health of the Russian Federation (Krasnoyarsk)

The aim of this study was to study the effectiveness of metabolic therapy in the treatment of polyneuropathy in patients with type 2 diabetes mellitus. The results of treatment of 110 patients with type 2 diabetes were analyzed. To study the efficacy and safety of metabolic drugs, patients were divided into 4 parallel groups: Group 1 (Control group), patients receiving only basic hypoglycemic therapy; group 2 (Cocarnit), patients who, in addition to basic hypoglycemic therapy, received a combined metabolic drug – "Cocarnit"; Group 3 (Cytoflavin), patients who, in addition to basic hypoglycemic therapy, received the combined metabolic drug "Cytoflavin"; group 4 (Thioctacid), patients who, in addition to basic hypoglycemic therapy, received the drug thioctic acid "Thioctacid". All patients were tested for TSS, NSS,NDS, SF-36, neurophysiological study – ENMG, as well as determination of VEGF in blood serum in dynamics in order to evaluate the effectiveness of metabolic therapy 24–48 hours before and after 36-40 days of therapy. According to the TSS and NSS scales, patients who received Cocarnit, Cytoflavin, and Thioctic acid had significantly higher confidence differences before and after thera-py (p
Keywords: 
type 2 diabetes mellitus
diabetic polyneuropathy
thioctic acid
cocarnitol
cytoflavin
metabolic therapy
electroneuromyography

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