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PROSPECTS FOR APPLICATIONS OF NANODIAMONDS IN MEDICINE (REVIEW)

DOI: https://doi.org/10.29296/25877313-2021-01-05
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Issue: 
1
Year: 
2021

G.M. Berdichevskiy Post-graduate Student Department of Biological Chemistry, Pavlov First Saint Petersburg State Medical University(Saint Petersburg) E-mail: grishaberd@gmail.com L.V. Vasina Dr.Sc. (Med.), Head of the Department of Biological Chemistry, Pavlov First Saint Petersburg State Medical University(Saint Petersburg) E-mail: lubov.vasina@gmail.com. E.V. Ryumina Ph.D. (Biol.), Assistant Professor, Department of Biological Chemistry, Pavlov First Saint Petersburg State Medical University (Saint Petersburg) E-mail: evrumina2@mail.ru V.V. Sharoyko Dr.Sc. (Biol.), Professor, Department of General and Bioorganic Chemistry, Pavlov First Saint Petersburg State Medical University (Saint Petersburg) E-mail: sharoyko@gmail.com K.N. Semenov Dr.Sc. (Chem.), Head of the Department of General and Bioorganic Chemistry, Pavlov First Saint Petersburg State Medical University (Saint Petersburg) E-mail: knsemenov@gmail.com

Nowadays, detonation nanodiamonds are considered by researchers as promising nanocarriers in the fields of biologically active substances and drug delivery systems. The possibility of using detonation nanodiamonds in biomedicine is due to the presence of a set of unique physicochemical properties, namely: nanodiamonds have a large specific surface area, stable fluorescence, biocompatibility, the ability to adsorb or conjugate with drugs. These properties of detonation nanodiamonds determine their use to create biomarkers, biosensors, highly effective adsorbents, catalysts for deactivation of toxins, dental composite materials. The procedure for standardisation and unification of industrially produced detonation nanodiamonds significantly expands the prospects for their application in medicine. The purpose of this review is to analyse the works of domestic and foreign scientists, which consider the use of detonation nanodiamonds not only as nanocarriers in delivery systems of cytostatics for the treatment of cancer, but also for the targeted delivery of a number of drugs for the treatment of other pathologies. The review article will be useful for specialists working in the field of nanomedicine and nanoengineering.
Keywords: 
detonation nanodiamonds
delivery system
DND-Amic
DND-glycine
DND-doxorubicin

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