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STUDY OF THE ANTI-DIABETIC ACTIVITY OF HELICHRYSUM THIANSCHANICUM REGEL. IN ALLOXANHYDRATE DIABETES MODEL

DOI: https://doi.org/10.29296/25877313-2021-02-07
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Issue: 
2
Year: 
2021

M.U. Sharofova Ph.D., Director of Institute of Avicenna’s Medicine and Pharmacology; Head of the Laboratory, ResearchCenter for Innovative Technologies at the National Academy of Sciences of Tajikistan (Dushanbe) E-mail: mijgona72@mail.ru Sh.S. Sagdieva Ph.D. (Med.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna’s Medicine and Pharmacology (Dushanbe) E-mail: shoistass@mail.ru S.J. Yusufi Doctor of Pharmaceutical Sciences, Professor, Academician of the Academy of Medical Sciences of the Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Department of Pharmacognosy and Fundamentals of Pharmacy Economics, Avicenna Tajik State Medical University (Dushanbe) E-mail: salomudin@mail.ru S.R. Numonov Ph.D. (Chem.), Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna’s Medicine and Pharmacology (Dushanbe) E-mail: sodikjon82@gmail.com R.U. Rahmonov Senior Research Scientist, Research Center for Innovative Technologies at the National Academy of Sciences of Tajikistan; Institute of Avicenna’s Medicine and Pharmacology (Dushanbe) E-mail: rahmon777@list.ru E.V. Ferubko Ph.D. (Med.), Head of Department of Experimental Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: ferubko@vilarnii.ru I.A. Lupanova Ph.D. (Biol.), Head of the Center for Preclinical Research, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow) E-mail: lupanova@vilarnii.ru

Relevance. The limited herbal medicines list is usedto prevent and treat the diabetes mellitus at present. The prospective raw material for such in-vestigations is the Helichrysum thianschanicum Regel., the medicinal plant that widely grows in Tajikistan. The aim of the study was to investigate the antidiabetic properties of the Helichrysum thianschanicum Regel. flowers and leaves infusion in experi-mental diabetes model. Material and methods. We used 36 white nonlinear rats of both sexes weighing 180-220 grams. Flowers and leaves of the Helichrysum thianschani-cum Regel. were collected in the Darvaz region (2400m above sea level)  the Republic of Tajikistan in July-August 2016-2017. The study of the antidia-betic activity was performed on the alloxan diabetes model in rats. Results. It was found that the Helichrysum thianschanicum Regel. flowers and leaves infusion has a significant antidiabetic and metabolism-corrective effect, improving the functional parameters of the kidneys and liver, has a antiatherogenic activity. Conclusion. The results show that the Helichrysum thianschanicum Regel. flowers and leaves infusion has potential for preclinical research and antidia-betic drug development.
Keywords: 
Helichrysum thianschanicum Regel.
alloxanhydrate diabetes

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