THE PRECLINICAL STUDY ON THE SAFETY OF ADAPTOGENIC HERBAL REMEDY

The purpose of this work is to determine chronic toxicity, as well as the possible local irritating and mutagenic effect of a complex herbal remedy. Material and methods. The studies were performed on white Wistar rats. The effect of an extract of a dry complex herbal remedy on the morphofunctional state of internal organs was assessed after its three-month administration (per os) at doses of 100 and 500 mg/kg. The possible locally irritating and mutagenic effect of the investigational agent was determined with its single administration at doses of 100 and 1000 mg/kg. Results. It was found that long-term administration of the investigational agent promotes an increase in the research activity of animals, exhibits a diuretic effect, and also reduces the level of cholesterol, the content of urea and creatinine in the serum of white rats. A single administration of the test agent in doses of 100 and 1000 mg/kg does not have a local irritating effect on the mucous membrane of the digestive tract and does not exhibit a mutagenic effect. Conclusions. The investigated agent, with long-term administration, does not have a toxic effect on the morphofunctional state of internal organs, with a single administration-locally irritating and mutagenic effects.