THE PRECLINICAL STUDY ON THE SAFETY OF ADAPTOGENIC HERBAL REMEDY

DOI: https://doi.org/10.29296/25877313-2021-04-04
Issue: 
4
Year: 
2021

Ya.G. Razuvaeva Dr.Sc. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude, Russia) E-mail: tatur75@mail.ru A.A. Toropova Ph.D. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude, Russia) V.G. Banzaraksheev Ph.D. (Med.), State University named after Dorzhi Banzarova (Ulan-Ude, Russia) V.V. Ayusheeva Leading Engineer, Institute of General and Experimental Biology SB RAS (Ulan-Ude, Russia)

The purpose of this work is to determine chronic toxicity, as well as the possible local irritating and mutagenic effect of a complex herbal remedy. Material and methods. The studies were performed on white Wistar rats. The effect of an extract of a dry complex herbal remedy on the morphofunctional state of internal organs was assessed after its three-month administration (per os) at doses of 100 and 500 mg/kg. The possible locally irritating and mutagenic effect of the investigational agent was determined with its single administration at doses of 100 and 1000 mg/kg. Results. It was found that long-term administration of the investigational agent promotes an increase in the research activity of animals, exhibits a diuretic effect, and also reduces the level of cholesterol, the content of urea and creatinine in the serum of white rats. A single administration of the test agent in doses of 100 and 1000 mg/kg does not have a local irritating effect on the mucous membrane of the digestive tract and does not exhibit a mutagenic effect. Conclusions. The investigated agent, with long-term administration, does not have a toxic effect on the morphofunctional state of internal organs, with a single administration-locally irritating and mutagenic effects.

Keywords: 
Serratula centauroides L.
Echinacea purpurea L. Moench
Rosa spp.
Inula helenium L.
Bergenia crassifolia L. Fritsch
chronic toxicity
local irritant effect
mutagenic effects

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