DEPENDENCE OF THE EFFICIENCY OF VITAMIN D DEFICIENCY CORRECTION AND ITS CONSEQUENCES IN RATS FROM SUPPLY WITH B GROUP VITAMINS

DOI: https://doi.org/10.29296/25877313-2021-04-05
Issue: 
4
Year: 
2021

V.M. Kodentsova Dr.Sc. (Biol.), Professor, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID 0000-0002-5288-1132 E-mail: kodentsova@ion.ru S.N. Leonenko Posr-graduate student, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-0048-4220 N.A. Beketova Ph.D. (Chem.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-2810-2351 O.V. Kosheleva Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-2391-9880 O.A. Vrzhesinskaya Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID 0000-0002-8973-8153 A.A. Sokolnikov Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-1808-652X L.V. Shevyakova Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0002-7447-8520 D.V. Risnik Ph.D. (Biol.), Leading Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0002-3389-8115 S.N. Zorin Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-2689-6098

Kumar R., Haq A., Wimalawansa S.J., Sharma A. Putative roles of vitamin D in modulating immune response and im¬munopathology associated with COVID-19. Virus Res. 2021; 292: 198235. doi: 10.1016/j.virusres.2020.198235. Maghbooli Z., Sahraian M.A., Ebrahimi M., Pazoki M., Kafan S., Tabriz H.M., Hadadi A., Montazeri M., Nasiri M., Shirvani A., Holick M.F. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS One. 2020;15:e0239799. doi: 10.1371/journal.pone.0239799. Xu Y., Baylink D.J., Chen C.S., Reeves M.E., Xiao J., Lacy C., Lau E., Cao H. The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotec¬tive treatment for COVID-19. J. Transl. Med. 2020; 18: 322. doi: 10.1186/s12967-020-02488-5. Желтикова Т.М., Денисов Д.Г., Мокроносова М.А. Ген¬дерные и возрастные особенности статуса витамина D (25(ОН)D) в России. Русский медицинский журнал. 2019; (12): 51–56. Вильмс Е.А., Турчанинов Д.В., Юнацкая Т.А., Сохошко И.А. Оценка витаминной обеспеченности населения крупного административно-хозяйственного центра Западной Сиби¬ри. Гигиена и санитария. Коденцова В.М., Бекетова Н.А., Никитюк Д.Б., Тутельян В.А. Характеристика обеспеченности витаминами взрослого населения Российской Федерации. Профилактическая меди-цина. 2018; 21(4):3237 doi: 10.17116/profmed201821432. Спиричев В.Б. О биологических эффектах витамина D. Педиатрия. Журнал им. Г.Н. Сперанского. 2011; 90(6): 113–119. Коденцова В.М., Вржесинская О.А. Влияние дефицита витаминов на обеcпеченность организма витамином D. Вопросы биологической, медицинской и фармацевтичес¬кой химии. 2018; 21(7): 42−46. doi: 10.29296/25877313-2018-07-07. Dai Q., Zhu X., Manson J.E., Song Y., Li X., Franke A.A., Costello R.B., Rosanoff A., Nian H., Fan L., Murff H., Ness R.M., Seidner D.L., Yu C., Shrubsole M.J. Magnesium status and supplementation influence vitamin D status and meta¬bolism: results from a randomized trial. Am. J. Clin. Nutr. 2018, 108(6):12491258. doi: 10.1093/ajcn/nqy27. Коденцова В.М., Рисник Д.В. Микронутриентные мета-болические сети и множественный дефицит микронут¬риентов: обоснование преимуществ витаминно-мине¬ральных комплексов. Микроэлементы в медицине. 2020; 21(4):3−20. doi: 10.19112/2413-6174-2020-21-4-3-20. Sechi G., Sechi E., Fois C., Kumar N. Advances in clinical determinants and neurological manifestations of B vitamin deficiency in adults. Nutr. Rev. 2016; 74(5): 281300. doi: 10.1093/nutrit/nuv107. Вржесинская О.А., Коденцова В.М., Бекетова Н.А., Переверзева О.Г., Кошелева О.В. Экспериментальная мо¬дель алиментарного полигиповитаминоза разной степени глубины у крыc. Вопросы питания. 2012; 81(2): 5156.

Keywords: 
combined deficiency of vitamins D and B group
correction of vitamin D deficiency
blood plasma
liver
brain
urine
rats

References: 
  1. Kumar R., Haq A., Wimalawansa S.J., Sharma A. Putative roles of vitamin D in modulating immune response and im¬munopathology associated with COVID-19. Virus Res. 2021; 292: 198235. doi: 10.1016/j.virusres.2020.198235.
  2. Maghbooli Z., Sahraian M.A., Ebrahimi M., Pazoki M., Kafan S., Tabriz H.M., Hadadi A., Montazeri M., Nasiri M., Shirvani A., Holick M.F. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS One. 2020;15:e0239799. doi: 10.1371/journal.pone.0239799.
  3. Xu Y., Baylink D.J., Chen C.S., Reeves M.E., Xiao J., Lacy C., Lau E., Cao H. The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotec¬tive treatment for COVID-19. J. Transl. Med. 2020; 18: 322. doi: 10.1186/s12967-020-02488-5.
  4. Zheltikova T.M., Denisov D.G., Mokronosova M.A. Genderand age-related characteristics of vitamin D (25(ОН)D) in Russia. RMJ. 2019; (12):51-56 (in Russian).
  5. Wilms E.A., Turchaninov D.V., Yunatskaya T.A., Sokhoshko I.A. Assessment of vitamin provision of the population of the large administrativean deconomic center of the Western Siberia. Hygiene and sanitation. 2017; 96(3): 277-280 (in Russian).
  6. Kodentsova V.M., Beketova N.A., Nikitjuk D.B., Tutelyan V.A. Characteristics of vitamin provision in the adult population of the Russian Federation the Russian Jour-nal of Preventive Medicine. 2018; 21(4): 32-37. doi: 10.17116/profmed201821432 (in Russian).
  7. Spirichev V.B. On the biological effects of vitamin D. Pediatrics. Journal named after G.N. Speransky. 2011; 90(6): 113-119 (in Russian).
  8. Kodentsova V.M., Vrzhesinskaya О.А. The influence of the vitamin deficiency on the sufficiency of the organism with vitamin D. Problems of Biological, Medical and Pharmaceutical Chemistry. 2018; 21(7): 42−46. doi: 10.29296/25877313-2018-07-07 (in Russian).
  9. Dai Q., Zhu X., Manson J.E., Song Y., Li X., Franke A.A., Costello R.B., Rosanoff A., Nian H., Fan L., Murff H., Ness R.M., Seidner D.L., Yu C., Shrubsole M.J. Magnesi-um status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am. J. Clin. Nutr. 2018, 108(6):1249-1258. doi: 10.1093/ajcn/nqy27.
  10. Kodentsova V.M., Risnik D.V Micronutrient metabolic networks and multiple micronutrient deficiency: a rationale for the advantages of vitamin-mineral supplements. Microelements in medicine. 2020; 21(4):3−20. doi: 10.19112/2413-6174-2020-21-4-3-20 (in Russian).
  11. Sechi G., Sechi E., Fois C., Kumar N. Advances in clinical determinants and neurological manifestations of B vitamin deficiency in adults. Nutr. Rev. 2016; 74(5): 281-300. doi: 10.1093/nutrit/nuv107.
  12. Vrzhesinskaya O.A., Kodentsova V.M., Beketova N.A., Pereverzeva O.G., Kosheleva O.V. The experimental model of alimentary polyhypovitaminosis of different degree in rats. Voprosy pitaniia [Problems of Nutrition]. 2012; 81(2): 51-56. (in Russian).