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SCIENTIFICALLY BASED APPROACH TO SELECTION OF DRUG COMPONENTS FOR TREATMENT OF WOUNDS OF DIFFERENT GENESIS

DOI: https://doi.org/10.29296/25877313-2021-08-05
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Issue: 
8
Year: 
2021

N.V. Pyatigorskaya Dr.Sc. (Pharm.), Professor, Head of the Depаrtment of Industriаl Phаrmacy, Sеchenov First Moscow State Medical University (Sеchenov University) (Moscow, Russia) V.S. Kargin Post-graduate Student, the Department of Industrial Pharmаcy, Sеchenov First Moscow State Medical University (Sеchenov University) (Moscow, Russia) E-mail: kvc12.kargin@yandex.ru G.E. Brkich Ph.D. (Pharm.), Head of the Phаrmaceutical Technology Center, Sеchenov First Moscow State Medical University (Sеchenov University) (Moscow, Russia)

In modern conditions, increasing production and expanding the range of medicines, including those for external use, is inextricably linked with an increase in their quality. The existing dosage forms for external use, despite their widespread use in the pharmacotherapy of various diseases, do not fully meet modern requirements. This dictates the urgent need to create new drugs for external use. Of particular importance are the increased requirements for drugs for the treatment of wounds of various origins, which, along with the wound healing effect, should provide a pronounced osmotic effect in the wound, stimulate the growth of granulation and have a positive effect on the formation of local factors of immunological activity. Such a range of properties can be achieved only by creating combined drugs containing components with certain desired properties in combination with a scientifically grounded composition of excipients that actively affect the release, absorption, biotransformation and, ultimately, a more pronounced pharmacological effect of active substances. Considerable attention is paid to the problems of choosing a drug for external use for the treatment of external diseases in the literature. However, the results of treatment of patients leave much to be desired. The solution to this problem lies in the creation of new antimicrobial drugs, based on the search and selection of modern components for the pharmaceutical development of a therapeutically effective drug. The aim of the work is to conduct an information and analytical search for the selection of components for the pharmaceutical development of a drug for the treatment of wounds of various origins. As a result of a consistent analysis of the available literature data on polymeric drugs for the treatment of wounds, the search for potential components of a long-acting drug based on chitosan for the treatment of wounds of various origins was carried out. For the pharmaceutical development of a drug for the treatment of wound infection and stimulation of healing, it is possible to use enzymes immobilized in the structure of the carrier-chitosan as an active substance.
Keywords: 
chitosan
enzymes
drugs wound healing

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