HISTOLOGICAL STUDIES OF ORGANISM RESPONSE TO THE APPLICATION OF LOCAL EFFECT ANTIMICROBIAL GEL ON ANIMAL MODEL

The modern methods of therapy include not only conventional approaches to treatment, but also the application of medical devices (MD) based on pol-ymers to prolong the therapeutic effect at the local level. To develop this kind of MD, a number of studies are required, including studies of local tissue reactions at the cellular level, studies of parenchymal organs and blood tests in order to determine the response of surrounding tissues to implantation and their general toxic effect. These stages became the task for the study of gels based on polyvinylpyrrolidone with the addition of antibiotics. The technology for the manufacture of gels and their sterilization consisted in the use of ɣ-irradiation and heat treatment. The gel samples were implanted into the femoral muscle group of experimental animals. Gels, based on polyvinylpyrrolidone were different in their physicochemical properties, specifically, gels had different viscoelastic properties. Despite the differences in properties no critical local and general pathologies have been identified. This result speaks about gels’ inertness to the surrounding tissues and the absence of toxicity. The main reason for the aseptic inflammatory response of tissues is the difference in the viscoelastic properties of the gels.