CRITERIA FOR EVALUATING THE QUALITATIVE AND QUANTITATIVE CHARACTERISTICS OF MICROCAPSULES

DOI: https://doi.org/10.29296/25877313-2021-12-02
Issue: 
12
Year: 
2021

O.A. Semkina Ph.D. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) E-mail: semkinaolga@gmail.com O.M. Beloshapkina Post-graduate Student, Lomonosov Moscow State University; All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) M.A. Dzhavakhyan Dr.Sc. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

The review presents material on the peculiarities of methods for assessing the quality of microcapsules of drug substances and the potential applica-tion of formal techniques and additional tests proposed for active pharmaceutical substances enclosed in microcapsules. We analyzed domestic and foreign sources of open access literature; the following digital databases were used: PubMed, Elibrary, CyberLenincka and the Google Scholar search engine. The effective tests proposed for microencapsulated substances and the need for additional tests for microcapsules depending on their compo-sition and purpose were identified. Opportunities of microcapsules standardization as a dosage form for effective evaluation and understanding of quali-tative and quantitative characteristics while considering microparticles as a pharmaceutical substance and a dosage form intended for use were de-scribed.

Keywords: 
microcapsules
encapsulation
standardization
quality assessment
microencapsulation
trials

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