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PREDICTION OF MECHANISMS OF PHARMACOLOGICAL ACTION OF A MULTICOMPONENT HERBAL EXTRACT USING THE PASS ONLINE WEB RESOURCE ON THE EXAMPLE OF THE HERB OF CHICORIA

DOI: https://doi.org/10.29296/25877313-2021-12-05
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Issue: 
12
Year: 
2021

G.V. Adamov Ph.D (Pharm.), Research Scientist, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) E-mail: grig.adamov@mail.ru O.L. Saybel Ph.D (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia) P.G. Mizina Dr.Sc. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

Prediction of the biological activity of chemical compounds before conducting biological analyzes is now a common practice. Preliminary screening us-ing software and mathematical methods allows you to identify the most promising chemical compounds and thereby significantly save expended re-sources, including reducing the number of required laboratory animals. For the first time, the article proposes to use the prediction of pharmacological activity for total herbal preparations. For this, using the open platform PASS online, the pharmacological activity of phenolic acids of chicory was predicted, and the effects were identified that coincide for most of the se-lected compounds. This approach makes it possible to level the probabilistic nature of the assessment for each individual compound and to suggest synergistic interactions.
Keywords: 
PASS
Cichorium intybus
caftaric acid
caffeic acid
chlorogenic acid
chicory acid

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