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FEATURES OF METABOLISM AND SPECTRUM OF ACTION OF SELENIUM, POSSIBILITIES OF APPLICATION OF SELENE-CONTAINING FOOD SUPPLEMENTS UNDER SARS-COV-2 PANDEMIC CONDITIONS

DOI: https://doi.org/10.29296/25877313-2022-03-04
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Issue: 
3
Year: 
2022

E.V. Okladnikova Ph.D. (Med.), Associate Professor of the Department of Pharmacology and Сlinical Рharmacology with a Postgraduate Course, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation (Krasnoyarsk, Russia) T.V. Potupchik Ph.D. (Med.), Associate Professor of the Department of Pharmacology and Сlinical Рharmacology with a Postgraduate Course, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation (Krasnoyarsk, Russia) E-mail: potupchik_tatyana@mail.ru L.S. Evert Dr.Sc. (Med.), Chief Researcher, the Clinical Department of Somatic and Mental Health of Children, Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences", Research Institute of Medical Problems of the North – a Separate Division (Krasnoyarsk, Russia); Professor, the Department of General Professional Disciplines, Medical, Psychological and Social Institute, N.F. Katanov Khakass State University named after (Abakan, Republic of Khakassia, Russia) O.F. Veselova Ph.D. (Med.), Head of the Department of Pharmacology and Сlinical Рharmacology with a Postgraduate Course, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation (Krasnoyarsk, Russia) Ya.E. Shirobokov Post-graduate Student, Department of Management and Economics of Pharmacy, Samara State Medical University (Samara, Russia)

This article provides a literary review of domestic and foreign sources reflecting the prevalence of selenium (Se) in the environment, its metabolism in the human body. It has been shown that Se deficiency is associated with cardiovascular diseases, disorders in the endocrine and reproductive sys-tem. The role of Se in the antioxidant defense system that supports the redox homeostasis of the cell and the body, for example, in viral infections, one of the causes of which is oxidative stress, is presented. The above sources also reflect the positive role of Se in viral infections, including, with a new coronavirus infection caused by the SARS-CoV-2 virus, since Se is necessary for the differentiation and proliferation of a number of immune cells involved in the processes of innate and adaptive immunity. It has been proven that in moderate doses, the Se supplement increases the proliferation of T cells and the activity of natural killer cells. In this regard, it is possible to recommend taking dietary supplements containing Se in high-risk areas and /or shortly after suspected infection with SARS-CoV-2. Positive research results, as well as a good safety profile, indicate the possibility of using bio-logically active food additives containing Se in complex therapy, in particular SELENBIO for women in disorders of the cardiovascular, endocrine, repro-ductive system, as well as in infectious diseases
Keywords: 
selenium
metabolism
viral infections
COVID-19
SELENBIO for women

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