A.V. Malinovsky
Process Engineer, Special Design and Technology Bureau "Biofizpribor",
Branch of FSUE "EPM" FMBA of Russia (St. Petersburg, Russia)

After catabolism of all amino acids became known, attempts to make up a scheme of ways of introducing amino acids’carbon skeletons in different stages of oxydative transformations in Krebs cycle were made several times; amino acids having been united in groups. However, all schemes which are known so far have some faults particularly referring to glucogenic or ketogenic effects of one or another amino acid. Moreover, the conclusion to which the scientists came with reference to this effect, do not always correspond to the scheme. Faults both in the sceme and conclusions concern-ing glucogenic and ketogenic effects of amino acids are not admissible; these effects can be clearly observed in case of diabetes: introduction of glu-cogenic amino acids into the organism reduces the severity of ketosis whereras that of ketogenic increases it. In the present paper a scheme of introducing amino acids’carbon skeletons into Krebs cycle, specified on the basis of modern data of amino acids’ transformation, and conclusions of glucogenic or ketogenic effects of one or another amino acid that fully correspond to the scheme are given. The re-sults should be taken into account when dealing with diabetes and some other diseases.

amino acids
glucogenic effect
ketogenic effect.

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