STUDY OF THE INFLUENCE OF STRUCTURAL AND MECHANICAL PARAMETERS OF GELLING AGENTS FOR THE CREATION OF SOFT DOSAGE FORMS WITH GINKGO BILOBA EXTRACT

DOI: https://doi.org/10.29296/25877313-2022-05-07
Issue: 
5
Year: 
2022

E.V. Kovtun
Ph.D. (Pharm.), Associate Professor,
Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
ORCID: 0000-0003-3437-760X
E-mail: elena.f.73@mail.ru

Relevance. The issues of creating domestic phytopreparations closely related to the problem of import substitution in pharmacy are significant. In this regard, the development of the composition and technology of nasal gel, using dry ginkgo biloba extract as an active component, for the treat-ment of chronic disorders of cerebral circulation, is very relevant. The purpose of study is to analyze the structural and mechanical parameters of the dosage form, the effect of excipients and active substance, to create a dosage form with the ginkgo biloba phytocomplex. Material and methods. To assess the effect of different concentrations of the chitosan gel-forming agent and the active substance on the structural and mechanical parameters of the dosage form, model compositions of gels were studied. Rheological characteristics of the samples were studied by rotational viscometry. Conclusion. Rheological characteristics of the dosage form have been established. The effect of the concentration of chitosan gel-forming agent and the active substance of dry ginkgo biloba extract on the structural and mechanical parameters of the dosage form was studied. The viscosity of solu-tions of high-molecular compounds was determined.

Keywords: 
ginkgo biloba dry extract
nasal gel
chitosan
rheological characteristics
violation of cerebral circulation.

References: 
  1. Shuiyuan Cheng, Feng Xu, Linling Li, Hua Cheng, Weiwei Zhang. Seasonal Pattern of Flavonoid Content and Related Enzyme Activities in Leaves of Ginkgo biloba L.Not. Horti Agrobot. 2012; 40(1): 98–106.
  2. Kurkina A.V., Dubishhev A.V., Korchagina D.V., Bulankin D.G., Zagoskina N.V. Ginkgo dvulopastnyj – perspektivnyj istochnik importozameshhenija nootropnyh lekarstvennyh preparatov. Tradicionnaja medicina. 2012; 5: 261–265.
  3. Gosudarstvennyj reestr lekarstvennyh sredstv. http://grls.rosminzdrav.ru.
  4. Spravochnik lekarstvennyh sredstv / https://www.vidal.ru.
  5. Rogachev I.O., Gladyshev V.V., Burlaka B.S., Kechin I.L. Sravnitel'nye issledovanija strukturno-mehanicheskih harakteristik intranazal'nyh mjagkih lekarstvennyh form nimodipina. Zaporozhskij medicinskij zhurnal. 2011; 13(3): 092–094.
  6. D'jachkova L.V., Truhacheva T.V., Zhebentjaev A.I. Izuchenie strukturno-mehanicheskih svojstv mazevyh osnov. Vestnik farmacii. 2012; 3(57): 23–28.
  7. Mikušová V., Mikuš P. Advances in Chitosan-Based Nanoparticles for Drug Delivery. Int J Mol Sci. 2021; 22(17): 9652. DOI: 10.3390/ijms22179652.
  8. Varlamov V.P., Mysjakina I.S. Hitozan v biologii, mikrobiologii, medicine i sel'skom hozjajstve. Mikrobiologija. 2018; 87: 595‒598.
  9. Varlamov V.P., Il'ina A.V., Shagdarova B.C., Lun'kov I.S., Mysjakina I.S. Hitin/hitozan i ego proizvodnye: fundamental'nye i prikladnye aspekty. Uspehi biolog-icheskoj himii. 2020; 60: 317–368.
  10. Vjazkost' (OFS.1.2.1.0015.15). XIV G.F. RF. Ch. 1. M. 2018. http: femb.ru/femb/pharmacopea.php.
  11. Maklakova A.A., Kondratjuk Ju.V., Voron'ko N.G., Derkach S.R. Reologicheskoe povedenie gelej zhelatiny s dobavkami anionnogo polisaharida. Izvestija KGTU. 2012; 25: 90–97.
  12. Kishhenko V.M., Stepanova Je.F., Vernikovskij V.V., Privalov I.M. Strukturno-mehanicheskie svojstva zashhitnoj plenki s aloje jekstraktom zhidkim i aktoveginom (stat'ja). Farmacija. 2018; 67(6): 30–34. DOI:10.29296/25419218-2018-06-06
  13. Issledovanie reologicheskih svojstv nefti. Referat. Himija. 2014-08-23
  14. Maksudova F.H., Karieva E.S. Izuchenie reologicheskih parametrov 5% gelja diklofenaka natrija. Vestnik farmacii. 2014; 4(66): 57–61.
  15. Smelova N.N., Kovalev V.V., Jarnyh T.G. Ispol'zovanie reologicheskih pokazatelej s cel'ju obespechenija kachestva mazej. Upravlіnnja jakіstju v farmacії. Mat. VІІІ nauch.-praktich. konf. (m. Harkіv, 23 travnja 2014 r.). H.: Vid-vo NFaU, 2014. S. 130.