EVALUATION OF ANTI-ULCER ACTIVITY OF BIOLOGICALLY ACTIVE COMPOUNDS IN ALDER LEAVES

DOI: https://doi.org/10.29296/25877313-2022-07-03
Issue: 
7
Year: 
2022

O.V. Mushkina
Ph.D. (Pharm.), Associate Professor,
Belarusian State Medical University (Minsk, Republic of Belarus)
E-mail: Olga7081@tut.by
N.S. Gurina
Dr.Sc. (Biol.), Professor,
Belarusian State Medical University (Minsk, Republic of Belarus)

Relevance. Erosive and ulcerative lesions of the stomach and duodenal ulcers are very common patology. Relevant is the development of new effec-tive gastroprotective herbal remedies. Alder leaves contain a complex biologically active compounds, which causes antioxidant, antimicrobial, wound healing and anti-inflammatory action. In folk medicine alder is used to treat diseases of the gastrointestinal tract, however, there are no experimental data on gastroprotective properties of alder leaves. Material and methods. The objects of the study were black alder leaves and gray alder leaves harvested July 2020. The gastroprotective effect of black and gray alder leaf extracts was studied on the model of indomethacin erosive-hemorrhagic mucosal lesions membranes of the stomach, which was caused by a single intragastric administration to Wistar rats of indomethacin at a dose of 35 mg/kg per os. Results. It was established that the index of antiulcer activity for water extracts from black alder leaves in case of administering before the damage to the mucous membrane by the ulcerogen was 2.74, in case of administering after modeling the pathology – 2.65. For decoctions of gray alder leaves, the index of antiulcer activity in case of administering before indomethacin exposure was 2.02, in case of using after indomethacin administra-tion was 2.5. The value of the index of antiulcer activity in all experimental groups is more than 2 confirms the presence of antiulcerogenic activity of biologically active compounds of black alder and gray alder leaves. Conclusion. Administration to white rats of water extracts of alder leads to a significant decrease in the amount ulcers in all experimental groups. Proven possibility of using for the treatment and prevention of erosive ulcerative lesions of the gastric mucosa of rats decoctions of black and gray al-der leaves on the model of "acute" indomethacin ulcer.

Keywords: 
ulcerative-erosive lesions of the stomach
gastroprotective effect
black alder
gray alder

References: 
  1. Bliznjuk A.I. Gastroduodenal'nye jazvy (patogenez, klinika, diagnostika, lechenie. Minsk: BGMU, 2010; 75 s.
  2. Chechulin E.S. Podhody k lecheniju jazvennoj bolezni zheludka i dvenadcatiperstnoj kishki v istoricheskom aspekte. Mezhdunarodnyj nauchno-issledovatel'skij zhurnal. 2020; 1(91): 8386.
  3. Ivashkin V.T., Maev I.V., Car'kov P.V. i dr. Diagnostika i lechenie jazvennoj bolezni u vzroslyh (Klinicheskie rekomendacii Rossijskoj gastrojenterologicheskoj asso-ciacii, Rossijskogo obshhestva kolorektal'nyh hirurgov i Rossijskogo jendoskopicheskogo obshhestva). Ross. zhurnal gastrojenterologii, gepatologii, ko-loproktologii. 2020; 30(1): 4970.
  4. Serbina N.A. Protivojazvennaja aktivnost' i nekotorye storony mehanizma dejstvija fitopreparata al'tan: Avtoref. … diss. kan. biol. nauk. Har'kov, 2004; 20 s.
  5. Kosolapov V.P. Gastrprotektivnoe dejstvie loheina i jeplira v jeksperimente: Avtoref. … diss. kan. farm. nauk. Pjatigorsk, 2005; 22 s.
  6. Zalygina E.V., Podpletnjaja E.A. Issledovanie protivojazvennoj aktivnosti gustogo jekstrakta iz nezrelyh plodov oreha greckogo na modeli indometacininducirovan-noj jazvy zheludka u krys. Farmakologіja ta lіkars'ka toksiko-logіja. 2017; 3(54): 4249.
  7. Zdravoohranenie v Respublike Belarus': ofic. stat. sb. za 2017 g., 2018 g., 2019 g., 2020 g., 2021 g. Minsk: GU RNMB [Jelektronnoe izdanie]. URL: www.belstat.gov.by.
  8. Borisova M.S. Protivojazvennaja aktivnost' proizvodnyh monoterpenov (jeksperimental'noe issledovanie): Avtoref. diss. … kan. biol. nauk. Novosibirsk, 2019; 129 s.
  9. Zacepina E.E. Jeksperimental'noe izuchenie gastroprotektornoj aktivnosti kombinirovannoj lekarstvennoj formy na osnove masla oblepihovogo: Avtoref. … diss. kan. biol. nauk. Volgograd, 2008; 24. s.
  10. Mushkina O.V. Farmakognosticheskij analiz list'ev ol'hi: Avtoref. … diss. kan. farm. nauk. Vitebsk, 2009; 20 s.
  11. Befungin instrukcija po primeneniju, opisanie lekarstvennogo preparata [Jelektronnyj resurs]. URL: https://www.vidal.by/poisk_preparatov/befungin-rastvor.html
  12. Ferbuko E.V., Nikolaev S.M., Pupykina K.A. Dargaeva T.D. Izuchenie protivojazvennoj aktivnosti kompleksnogo rastitel'nogo jekstrakta pri jeksperimental'nyh jazvah zheludka. Sovremennye problemy nauki i obrazo-vanija. 2018; 4 [Jelektronnyj resurs]. URL: http://www.scienceeducation.ru/ru/ar-ticle/view?id=27783. doi:1017513/spno.27783.
  13. Mamonova N.V., Zotova A.V., Egorkina A.A. Protivojaz-vennaja aktivnost' kompleksnogo sbora lekarstvennyh rastenij. Zdorov'e. Medicinskaja jekologija. Nauka. 2009; 45: 119121.