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THE MAIN DIRECTIONS OF PHARMACEUTICAL DEVELOPMENT OF PHYTOECDYSTEROID PREPARATIONS (REVIEW)

DOI: https://doi.org/10.29296/25877313-2022-08-01
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Issue: 
8
Year: 
2022

E.I. Molokhova
Dr.Sc. (Pharm.), Professor, Department of Industrial Technology of Drug with a Course in Biotechnology,
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy»
of the Ministry of Health of the Russian Federation (Perm, Russia)
D.E. Lipin
Ph.D. (Pharm.), Department of Industrial Technology of Drug with a Course in Biotechnology,
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy»
of the Ministry of Health of the Russian Federation (Perm, Russia)
Yu.V. Sorokina
Ph.D. (Pharm.), Associate Professor, Department of Industrial Technology of Drug with a Course in Biotechnology,
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy»
of the Ministry of Health of the Russian Federation (Perm, Russia);
Associate Professor, Department of Botany and Plant Physiology,
Federal State Budgetary Educational Institution of Higher Education «Perm State Agro-Technological University
named after Academician D.N. Pryanishnikov» (Perm, Russia)
E-mail: sorokinayulia@yandex.ru

Phytoecdysteroids (phytoecdysones) are polyhydroxylated sterols identical to arthropod hormones that have a wide range of pharmacological effects. Goal of review is to systematize information sources on the search for promising sources of raw materials for the isolation of phytoecdysteroids and the creation of drugs based on them. It has been found that plants representatives of families Caryophyllaceae, Lamiaceae genus Ajuga, Asteraceae genus Serratula are of interest as traditional medicinal plant raw materials representatives. The prospects of producing of phytoecdysteroids using the hairy roots culture are shown. The review shows the nomenclature of medicinal products and BAA based on phytoecdysteroids. Trends in the creation of effective dosage forms that increase the biological availability of phytoecdysones, including the development of nanoscale complexes, are highlighted.
Keywords: 
phytoecdysteroids (phytoecdysones)
20-hydroxyecdysone
serpukha crowned
serpistene
ointments
nanoscale forms

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