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IDENTIFICATION OF TINCTURES BY THE POLARIMETRIC METHOD

DOI: https://doi.org/10.29296/25877313-2022-09-01
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Issue: 
9
Year: 
2022

A.V. Syroeshkin
Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and Toxicological Chemistry,
Medical Institute, Peoples' Friendship University of Russia (Moscow, Russia)
Е-mail: livmatter@mail.ru
D.D. Ogotoeva
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry,
Medical Institute, Peoples' Friendship University of Russia (Moscow, Russia)
D.A. Galkina
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry,
Medical Institute, Peoples' Friendship University of Russia (Moscow, Russia)
M.A. Dzhavakhyan
Dr.Sc. (Pharm.), Chief Research Scientist,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
T.E. Elizarova
Ph.D. (Pharm.), General Manager «KoAl Farmanaliz» LLC (Moscow, Russia)
E.V. Uspenskaya
Dr.Sc. (Pharm.), Professor, Department of Pharmaceutical and Toxicological Chemistry,
Medical Institute, Peoples' Friendship University of Russia (Moscow, Russia)
T.V. Pleteneva
Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry,
Medical Institute, Peoples' Friendship University of Russia (Moscow, Russia)

Relevance. The ambiguity of the observed therapeutic effects of tinctures and the absence of pharmacopoeial articles require the development of new approaches to their quality control. In this work, for the first time, the polarimetry method and the dynamic light scattering method were used to identify tinctures with sedative and cardiotonic effects. The purpose. To develop the methods of polarimetry and dynamic light scattering for quality control of valerian, motherwort and hawthorn tinctures Material and methods. Objects of research: tinctures of rare series from different manufacturers. Methods: polarimetry (POL-1/2, Atago, Japan); dynamic light scattering method - DLS (Zetasizer Nano ZS, Malvern, UK). Results. Polarimetric method established that tinctures are optically active environment. This made it possible to develop a method for identifying tinctures with sedative and cardiotonic effects, which is based on measuring the optical rotation angle of 95% ethanol dilutions of different multiplici-ties. When diluting valerian tincture in a ratio of 1:40, the angle of optical rotation is in the range of −0.10°

Keywords: 
tinctures of valerian
motherwort
hawthorn
polarimetry
dynamic light scattering

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