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COMPARATIVE STUDY OF VITEX AGNUS-CASTUS FRUITS AND VITEX NEGUNDO FRUITS

DOI: https://doi.org/10.29296/25877313-2022-10-01
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Issue: 
10
Year: 
2022

G.V. Adamov
Ph.D. (Pharm.), Laboratory of Atomic and Molecular Bioregulation and Selection,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: adamov@vilarnii.ru
О.L. Saybel
Ph.D. (Pharm.), Center for Chemistry and Pharmaceutical Technology,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
Е.А. Konyaeva
Research Scientist, Center for Chemistry and Pharmaceutical Technology,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
I.А. Lupanova
Ph.D. (Biol.), Center for preclinical studies,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
А.N. Tsitsilin
Ph.D. (Biol.), Laboratory of the Botanical Garden,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, (Moscow, Russia)

The purpose of the work is to identify differences in the morphological and anatomical structure, chemical composition and biological activity of the fruits of VA and VN to justify the rationing of impurities and harmonize the quality requirements for VA fruits with foreign pharmacopoeias. Material and methods. The objects of the study were the fruits of the VA harvested in the Republic of Crimea and the fruits of the VN, collected in the Krasnodar Territory in 2019. To develop a method for identifying the admixture of the fruits of the VN in the fruits of the VA, their microscopic analy-sis, phytochemical study and assessment of biological activity were carried out. To identify differences in the anatomical structure, the outer epider-mis of the calyx of the fetus and crushed micropreparations of the fetus were studied, microphotographs were taken. As diagnostic features, the pres-ence of drusen and calcium oxalate crystals in the parenchyma of the fruits of the VN, a different structure of simple and glandular hairs are indicated. Phytochemical study was carried out using the method of high performance liquid chromatography with ultraviolet detection. Results. Under these conditions, in addition to the casticin used in the European Pharmacopoeia 8.0, two more marker compounds were identified. To substantiate the inadmissibility of the fruits of the VN in the fruits of the VA, a screening study of biological activity in vitro in relation to the activation of dopamine receptors was carried out. Conclusions. VN does not show targeted pharmacological properties and cannot be used as a medicinal plant material along with VA
Keywords: 
Vitex agnus-castus
biotest system
Vitex negundo
microscopic analysis

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