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CHEMOMETRIC APPROACH TO INVESTIGATION OF THE ROLE OF ADIPOSE TISSUE AS A TARGET FOR TOXIC METAL EFFECTS
DOI: https://doi.org/10.29296/25877313-2022-12-01
Issue:
12
Year:
2022
The objective of the present study was to assess toxic metal content in human adipose tissue and evaluate patterns of toxic and essential trace el-ement accumulation in adipose tissue compared to liver.
Material and methods. The samples of right-sided pararenal adipose tissue and right lobe of the liver were obtained from autopsy of 28 patients aged from 33 to 63 years old who died from complications of cardiovascular diseases.
Results. Assessment of toxic and essential element levels was performed using inductively-coupled plasma mass spectrometry. The obtained data demonstrate comparable levels of toxic metals in adipose tissue and liver. Specifically, no significant group difference in aluminium and arsenic con-tent was observed between liver and adipose tissue. Lead and tin content in adipose tissue was 23% and 46% lower than that in liver, respectively. At the same time, the levels of cadmium and mercury in liver exceeded the respective values in adipose tissue by a factor of 2.6 and 4.5. In view of manyfold differences in total protein levels in adipose tissue and liver, toxic metal accumulation in adipocyte cytoplasm far exceeds that in hepato-cytes.
Conclusion. Therefore, the obtained data demonstrate that adipose tissue may be considered as a target for toxic metal effects, thus underlying the epidemiological association between toxic metal exposure and obesity prevalence
Keywords:
adipose tissue; adipocyte; toxicity; arsenic; metals
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