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PHARMACEUTICALS BASED ON ZIZYPHI FRUCTUS COMPOUNDS IN GASTROINTESTINAL ILLNESS TREATMENTS: THE PROSPECTS OF APPLICATION

DOI: https://doi.org/10.29296/25877313-2022-12-03
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Issue: 
12
Year: 
2022

O.A. Semkina
Ph.D. (Pharm.), Leading Research Scientist of the Experimental and Technological Department,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: semkina@vilarnii.ru
Y.V. Asaturov
Post-graduate Student,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E.V. Borisenko
Ph.D. (Veterinary), Leading Research Scientist of the Scientific and Organizational Department,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

Currently, plant-derived medicines have a long history of use for the prevention and therapy of human disease, and to the treatment of gastrointestinal illness disorder in particular. With that, one of the topical problem of pharmacy is to research phytochemical composition of plants, innovation technol-ogies of manufacturing plant - based extracts in order to create new biologically active compositions for the pharmaceutical industry use. This paper is concerned with gathering the current knowledge related to the medicinal characteristics the fruit of Z. Jujuba Mill. Specifically, its phytochemical con-tents and pharmacological activities in the treatment of gastrointestinal illness disorder. Particular attention has been given to the sum of the main phytochemicals, including flavonoids, saponins, glycosides, polysaccharides and triterpenic acids, which are responsible for the reported pharmacological properties of Zizyphi Fructus, including anti-inflammatory, antioxidant, antiucleric, hepa-toprotective and gastrointestinal activities. Authors was led to the conclusion that the sum of the knowledge on the Zizyphi Fructus based pharmaceuticals for gastrointestinal illness disorders is not far enough advanced and requires more in-depth study. Russian and foreign sources of literature placed in the public domain were analyzed; the following electronic databases were used: PubMed, elibrary, CyberLeninka and the Google-academy search engine.
Keywords: 
Ziziphus jujuba Mill.
fruits
flavonoids
antiulcer activity
anti-inflammatory activity

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