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STUDY AND SELECTION OF A MODEL SOLUTION CONTAINING ANTIBIOTICS TO DEVELOP AN EAR DROP TO TREAT OTITIS MEDIA

DOI: https://doi.org/10.29296/25877313-2023-01-04
Issue: 
1
Year: 
2023

Ghadeer Balloul
Master, Department Pharmaceutical and Chemical Technology,
The National Research University "Belgorod State University" (Belgorod, Russia)
E-mail: ghadeerballoul@gmail.com

Introduction. Otitis media is an infection of the middle ear, it happens in the space behind the eardrum which contains the tiny vibrating bones of the ear. it divided into acute otitis media (AOM), suppurative otitis media (SOM) and otitis media with effusion (OME). Otitis is the most common specific disease in children, children aged 0–12 registered in 62 practices (1 March 2019–29 February 2020) and (1 March 2020–28 February 2021) were includ-ed, and secondly, the problem of treating acute otitis media in of adults remains one of the most urgent problems of modern otolaryngology, treat-ment may begin with clear up pain and sometimes, antibiotics are used to clear the infection. The aim of the study – development of a therapeutic solution containing an antibiotic from fluoroquinolones group for the treatment of acute otitis media. Material and methods. Viscometer VPZH-2 0.39 EKROS, RUSSIA, Milwaukee MC120 PRO pH Monitor, Electronic stirrer. Analytical scales Sartogosm CE224-S. Preparation of HEC solutions, preparation of HPMC solutions. polymer solutions prepared according to USP standards. Results. The physical characteristics of the obtained mixtures were studied and the compositions of the model mixtures are shown. The solution, which contains benzyl alcohol, ofloxacin as active ingredients and HPMC with 70% ethanol as excipients, is fully meets the requirements of ear drops. Conclusions. Solution, which contains benzyl alcohol, ofloxacin as active ingredients and HPMC with 70% ethanol as excipients, has suitable viscosity and pH, which are fully meets the requirements of ear drops.
Keywords: 
Ear drops
HPMC
hypromellose
HEC
Hydroxyethylcellulose
Ear drop solution viscosity
pH
ofloxacin
Ethanol 70%
benzyl alcohol
Miramistin
References: 
  1. REFERENCES
  2. Meherali S., Campbell A., Hartling L., Scott S. Understanding Parents' Experiences and Information Needs on Pediatric Acute Otitis Media: A Qualitative Study. J Patient Exp. 2019; 6(1): 53–61. [PMC free article] [PubMed] [Reference list].
  3. Choffor-Nchinda E., Atanga L.C., Nansseu J.R., Djomou F. Effectiveness of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol. BMJ Open. 2018; 8(6): e021133. Published 2018 Jun 8. doi:10.1136/bmjopen-2017-021133
  4. Monasta L., Ronfani L., Marchetti F., Montico M., Vecchi Brumatti L., Bavcar A., et al. Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates. PLoS One. 2012; 7(4): e36226. https://doi.org/10.1371/jour-nal.pone.0036226.
  5. Monasta L., Ronfani L., Marchetti F., et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One. 2012; 7: e36226.
  6. Hullegie S., Schilder A.G.M., Marchisio P., de Sévaux J.L.H., van der Velden A.W., van de Pol A.C., Boeijen J.A., Platteel T.N., Torretta S., Damoiseaux R.A.M.J., Venekamp R.P. A Strong Decline in the Incidence of Childhood Otitis Media During the COVID-19 Pandemic in the Netherlands. Front Cell Infect Microbiol. 2021; Nov 1; 11:768377. doi: 10.3389/fcimb.2021.768377. PMID: 34790591; PMCID: PMC8591181.
  7. Massa H.M, Cripps A.W and Deborah Lehmann. Otitis media: viruses, bacteria, biofilms and vaccines. The Medical journal of Australia. 2009; 191(9). DOI: 10.5694/j.1326-5377. 2009.tb02926.x: 1-7.
  8. Dwyer D.J., Kohanski M.A., Hayete B., Collins J.J. Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol. Syst. Biol. 2007; 3:91. DOI: 10.1038/msb4100135.
  9. Kohanski M.A., DePristo M.A., Collins J.J. Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. Mol. Cell. 2010; 37: 311–320. DOI: 10.1016/j.molcel.2010.01.003.
  10. Koulich E., Roland P., Pawlowski K. Comparison of systemic and otic administration of ofloxacin. The Laryngoscope, 2010; Oct; ISSN: 1531-4995: 2.
  11. Adwan S., Abu-Dahab R., Al-Bakri A., Sallam A. Glyceryl monooleate-based otic delivery system of ofloxacin: release profile and bactericidal activity. Pharmaceutical development and technology. 2014; Jan; ISSN: 1097-9867: 1–6.
  12. Rowe R.C., Sheskey P.J., Quinn M.E. Handbook of pharmaceutical-excipients-6th-edition. 2009; 64–66.
  13. State Pharmacopoeia of the Russian Federation (SP RF) XIV, ОФС.1.2.1.0015.15 OFS viscosity.
  14. United State Pharmacopeia 44 - NF 39.
  15. State Pharmacopoeia of the Russian Federation (SP RF) XIV ofc. 1.4.1.0027.18 «drops».
  16. Balloul Ghadeer, Zhilyakova E.T., Boyko N.N., Al-rubaye Wisam Mahmud, Ivanova V.E., Malyutina A.Yu., Radyukova V.I., Moldavanova A.Yu. A comparison of the bactericidal activity of ofloxacin separately and in combination with benzyl alcohol against pathogenic microorganisms and fungi that cause otitis media. Meždunarodnyj naučno-issledovatel'skij žurnal (International Research Journal) 2021; 6(108): 26–30. (In Russian).