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STUDY OF THE ACCUMULATION OF GALLIUM-68-LABELED FOLIC ACID CONJUGATES IN VARIOUS ETIOLOGIES INFLAMMATION FOCI

DOI: https://doi.org/10.29296/25877313-2023-01-07
Issue: 
1
Year: 
2023

K.A. Lunyova
Research Scientist, Laboratory of Preclinical and Clinical Studies of Radiopharmaceuticals,
A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia;
Post-graduate Student, Department of Chemistry,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K.I. Skryabin (Moscow, Russia)
E-mail: christfmbc@gmail.com; ORCID ID: 0000-0002-1256-9873
A.A. Larenkov
Ph.D. (Chem.), Head of the Laboratory of Technology and Methods of Control of Radiopharmaceuticals,
A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia (Moscow, Russia)
E-mail: anton.larenkov@gmail.com; ORCID ID: 0000-0003-4810-4346
M.G. Rakhimov
Engineer, Laboratory of Technology and Methods of Control of Radiopharmaceuticals,
A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia (Moscow, Russia)
E-mail: marat.rakhimov89@gmail.com; ORCID ID: 0000-0002-7521-5976
A.S. Lunev
Ph.D. (Biol.), Senior Research Scientist, Laboratory of Preclinical and Clinical Studies of Radiopharmaceuticals,
A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia (Moscow, Russia)
E-mail: mr.alekslunev@gmail.com; ORCID ID: 0000-0002-8392-8343
O.E. Klementyeva
Ph.D. (Biol.), Head of the Laboratory of Preclinical and Clinical Studies of Radiopharmaceuticals,
A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia (Moscow, Russia)
E-mail: klementyeva.olga@gmail.com; ORCID ID: 0000-0002-6604-0860
F.I. Vasilevich
Dr.Sc. (Veterinary), Professor, Academician of the Russian Academy of Sciences,
Head of the Department of Parasitology and Veterinary and Sanitary Expertise,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K.I. Skryabin (Moscow, Russia)
E-mail: f-vasilevich@inbox.ru; ID: 0000-0003-0786-5317
A.E. Machulkin
Ph.D. (Chem.), Research Scientist, Lomonosov Moscow State University (Moscow, Russia)
E-mail: alekseymachulkin@rambler.ru; ORCID ID: 0000-0001-7975-0346

In recent years, folate receptors have been considered as a target for radiopharmaceutical drugs. For this purpose, new, previously unexplored com-pounds based on folic acid were synthesized. Objective. Study of the accumulation of gallium-68-labeled folic acid conjugates in various etiologies inflammation foci. Material and methods. The objects of the research were folic acid derivatives labeled with gallium-68. Systemic juvenile idiopathic arthritis was chosen as a pathology model. Acute inflammatory processes of soft tissues of septic and aseptic etiology were selected as differential models. Results. The results obtained in the study showed a significantly elevated level of accumulation in the juvenile idiopathic arthritis focus compared to healthy rat paws and accumulation in the foci of differential models of the inflammatory process, which confirms the macrophage-mediated pathway of accumulation of the studied compounds. Conclusion. The data obtained allow us to conclude about the diagnostic potential of radiolabeled conjugates based on folic acid in the radionuclide di-agnosis of rheumatoid and other diseases characterized by a pronounced macrophage immune response.
Keywords: 
folate receptors
gallium-68
positron emission tomography
radiopharmaceutical
juvenile idiopathic arthritis
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