X-RAY FLUORESCENCE DETERMINATION OF SILVER IN COLLOIDAL SOLUTIONS

Objective. To develop the basics of technology for X-ray fluorescence determination of silver in colloidal solutions. Relevance. Silver preparations are interesting as an alternative to antibiotics. Сurrently on the pharmaceutical market there is a large number of silver-containing colloidal dietary supplements, 70% of which contain silver in ionic form. The energy dispersive method of X-ray fluorescence analysis is an express method without long-term sample preparation. Materials and methods. Silver proteinate (8% Ag), Sigma-Aldrich; ProtargolLor (P.J.S.C. “Pharmstandard”, Kursk); Sialor (J.S.C. RENEWAL®); Argitos colloidal silver (“Nanosphere”, Russia), Argent Colloidal (Nutri expert, France). Dual Laser Light Scattering 2D-DLS (Zetasizer Malvern). Energy dispersive spectrometer Shimadzu EDX-7000 (Japan); OriginLab Corporation, USA. Results. The technology of the X-ray fluorescence determination of silver in colloidal solutions from various companies was described in this paper. The present study has exploited the energy dispersive spectrometer Shimadzu EDX-7000 (Japan). The fluorescence intensity at AgKα = 22.105 keV depends linearly on the silver concentration in the range of 0.01% - 1% according to the equation I = (5.1 ± 0.1) · СAg for silver nitrate and I = (1.64 ± 0.03) · CAg for silver proteinate, which is due to the effect of the organic matrix. Conclusion. The new XRF method was applied for quality control of protargol and other Ag-containing drugs and parapharmaceuticals.