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OXIDATIVE MODIFICATION OF PROTEIN AND RESERVE-ADAPTIVE POTENTIAL IN PATIENTS WITH METABOLIC PHENOTYPE OF OSTEOARTHRITIS
DOI: https://doi.org/10.29296/25877313-2023-06-06
Issue:
6
Year:
2023
Relevance. Oxidative stress, resulting from an imbalance between ROS production and the antioxidant defense system, is a major disruption of chronic inflammation in OA and obesity. It should be noted that the study and understanding of OS and their relationship with the identification of joint tissues is necessary to develop new therapeutic approaches to the occurrence and expediency of the metabolic phenotype of OA.
Aim. To study protein oxidative modification (OMP) and reserve-adaptive potential in patients with the metabolic phenotype of osteoarthritis (OA).
Material and methods. Participants were divided into 2 groups: Control group - patients without articular pathology, metabolic syndrome. The exper-imental group consisted of patients with the metabolic phenotype of OA. The subjects were collected complaints and anamnesis, as well as general clinical and orthopedic examination. In the blood serum, indicators of OMP and superoxidedismutase (SOD) were determined. Patients were asked to answer the questions of clinical scales of the functional state of the joints and quality of life.
Results. The initial activity of blood serum SOD was somewhat lower in patients with the metabolic phenotype of OA, and the level of OMP showed certain differences in the levels of activity of the processes of spontaneous and metal-catalyzed PMB. The total area under the spontaneous OMP curve was statistically significantly higher (p
Keywords:
obesity
osteoarthritis
superoxidedismutase
protein oxidative modification.
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