CORRECTION OF DAPSONE-INDUCED CHANGES IN LIVER FUNCTIONS BY EXTRACT OF LICORICE ROOTS NAKED

Relevance. To date, much attention is paid to an important aspect of pharmacotherapy aimed at improving the safety of drugs used in various diseases, as well as the search for means of correcting complications that have arisen as a result of the therapy. Antimicrobials occupy one of the leading places in the development of drug disorders on the part of various systems and organs, including the liver. In this regard, it is necessary to use means that correct functional disorders and improve metabolic processes in the liver. Licorice extract (Glycyrrhiza glabra) can be considered as such a remedy. The aim of the study was to evaluate the effect of licorice extract on dapsone–induced changes in liver function. Material and methods. All studies were conducted on non-linear white male rats (7 months) weighing 410.0 ± 20.0. The animals in the experiment were divided into groups (n=10): "control" - received purified intragastric water; "dapsone" – rats receiving intragastric dapsone (Novartis; Switzerland) once at a dose of 25 mg/kg for 30 days; "dapsone+licorice" – rats receiving oral dapsone in in the same mode and extract of licorice roots naked at a dose of 50 mg / kg intragastrically 1 time a day for 30 days. After the animals were removed from the experiment, the development of toxic liver damage and the degree of its correction were evaluated by determining the liver weight coefficient, the activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyltransferase, total protein, albumin, total bilirubin. Results. An analysis of the biochemical parameters of experimental animals with the use of licorice root extract under conditions of dapsone admin-istration for 30 days showed a decrease in the weight coefficient of the liver, levels of total protein and albumin, as well as a significant increase in transaminase activity, an increase in the level of bilirubin. Conclusion. The results obtained with the use of licorice root extract indicate the presence of hepatoprotective properties, manifested by correction of violations by biochemical parameters (reduced liver weight ratio, total protein and albumin levels, as well as significantly increased transaminase activity and increased bilirubin levels), indicating the development of hepatocellular disorders under the conditions of course administration of dapsone.