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PHARMACOPOEIAL METHODS FOR THE ANALYSIS OF CARDIAC GLYCOSIDES IN PLANT RAW MATERIALS AND MEDICINES (REVIEW)

DOI: https://doi.org/10.29296/25877313-2023-07-01
Issue: 
7
Year: 
2023

E.V. Bykov
Post-graduate Student, Analytical Chemistry Department, Perm State Pharmaceutical Academy (Perm, Russia)
E-mail: bykov.pfa@gmail.com
E.V. Vikhareva
Ph.D. (Pharm.), Professor, Head of the Analytical Chemistry Department, Perm State Pharmaceutical Academy (Perm, Russia)
E-mail: ajm@perm.ru

The review of modern methods of analysis of cardiac glycosides (CG) offered by pharmacopoeias of Russia, Europe, England, USA, India, Japan and China is presented. The purpose of the review is a comparative analysis of pharmacopoeial methods of identification and quantitative determination of the content of CG in plant raw materials and medicines. It is shown that in the Russian Pharmacopoeia, instrumental methods for the analysis of car-diac glycosides are not widely represented. In this regard, the search for effective methods of analyzing this group of substances in plant raw materi-als and medicines is relevant.
Keywords: 
pharmacopoeial methods of analysis
cardiac glycosides
medicinal plant raw materials
medicinal preparations.
References: 
  1. Clinical recommendations. Chronic heart failure. Ed. S.N. Tereshenko, A.S. Galyavich. M.: GEOTARD-Media. 2020; p. 183.
  2. Semenov A.A., Kartsev V.G. Biological activity of natural compounds. Moscow: International Charitable Foundation "Scientific Partnership". 2012; p. 520.
  3. Gurevich M.A., Gavrilin A.A. Cardiac glycosides in modern clinical practice. Almanac of clinical medicine. 2014; 35: 101–105.
  4. State Pharmacopoeia of the Russian Federation. XIV ed. V. 1. Moscow: FEMB. 2018. URL: https://docs.rucml.ru/feml/pharma/v14/vol4/1005 [date of request: 10.10.2022].
  5. State Register of Medicines. [Electronic resource] URL: https://grls.rosminzdrav.ru/grls.aspx?s=&m=mnn [date of request: 10.10.2022].
  6. European Pharmacopoeia. 11th edition. Council of Europe. Strasbourg Cedex, France: 2022; 1227–3513.
  7. British Pharmacopoeia. The British Pharmacopoeia Commission Secretariat of the Medicines and Healthcare Products Regulatory Agency (MHRA). London: 2022; 4: p. 576.
  8. The United States pharmacopoeia: USP 44; The national formulary: NF 39 United States Pharmacopeial. Rockville: 2021; p. 7968.
  9. Indian Pharmacopoeia. The Indian Pharmacopoeia Commission. Ghaziabad: 2022; 2: p. 670.
  10. Japanese Pharmacopoeia. 18th edition. Pharmaceutical Society of Japan. Tokyo: 2022; p. 2650.
  11. Chinese Pharmacopoeia. 11th edition. Chinese Pharmaceutical Association. Beijing: 2020; 2: p. 2184.
  12. El-Seedi H.R. Cardenolides: Insights from chemical structure and pharmacological utility. Pharmacological Research. 2019; 141: 123–175.
  13. Morsy N. Cardiac glycosides in medicinal plants. Aromatic and medicinal plants – back to nature. London: Intechopen, 1990; p. 29–45.
  14. Georgievsky V.P., Komissarenko N.F., Dmitruk S.E. Biologically active substances of plants. Novosibirsk: "Science" Siberian branch. 1990; p. 72.
  15. Orynbekova S.O., Keleke A.S., Sakipova Z.B., Ibragimova L.N., Sermukhamedova O.V., Nurgozhin T.S. Comparative evaluation of methods of identification of cardiac glycosides in medicinal plant raw materials. Bulletin of the Kazakh National Medical University. 2019; 2: 396.
  16. Mukherjee Pulok K. Quality Control and Evaluation of Herbal Drugs: Evaluating Natural Products and Traditional Medicine 1st Edition. Amsterdam: Elsevier. 2019; 237–328.
  17. Kruglov D.S., Koshkareva K.E. Quantitative determination of convallatoxin in plant raw materials containing cardiosteroids by photometry. Siberian Medical Bulletin. 2019; 4: 34–37.
  18. Malysheva S.V., Patrick P.J. Mulder, Masquelier J. Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market. Toxins (Basel). 2020; 12(4): 243.
  19. Watson E., Clark D.R., Kalman S.M. Gas Chromatographic – Identification by gas chromatography-mass spectroscopy of dihydrodigoxin – a metabolite of digoxin in man. Journal of Pharmacology and Experimental Therapeutics. 1973; 184 (2): 424–431.