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DEVELOPMENT OF A GEL FOR ADMINISTRATION TO CORRECT BLOOD LEVELS

DOI: https://doi.org/10.29296/25877313-2023-08-02
Issue: 
8
Year: 
2023

M.A. Dzhavakhyan
Dr.Sc. (Pharm.), Associate Professor, Head of Director of the Scientific and Educational Institute of Pharmacy,
Moscow State University of Medicine and Dentistry A.I. Evdokimova;
Chief Research Scientist, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: akopovamarina13@mail.ru
N.R. Pavec
Applicant, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
O.A. Semkina
Ph.D. (Pharm.), Leading Research Scientist, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
K.А. Pupykina
Dr.Sc. (Pharm.), Professor of the Department of Pharmacognosy with a Course of Botany and the Basics of Phytotherapy,
Bashkir State Medical University (Ufa, Russia)
D.V. Kurkin
Dr.Sc. (Pharm.), Director of the Scientific and Educational Institute of Pharmacy,
Moscow State University of Medicine and Dentistry A.I. Evdokimova
А.А. Маrkaryan
Dr.Sc. (Pharm.), Vice-Rector, Moscow State University of Medicine and Dentistry A.I. Evdokimova

Relevance. Medicinal plants are traditionally used as components that make up a healthy lifestyle program, prevention and treatment of certain dis-eases, including diabetes mellitus. Aim: to develop and justify the composition of the gel for oral administration in the treatment of type 2 diabetes mellitus in a dosage form convenient for the patient for self-administration. Material and methods. The object of the study is a standardized dense collection of the collection of the medicinal substance, the presence of rhi-zomes and high elecampane of high growth (Inula helenium L., rhizomata et radices), lingonberry leaves (Vaccinium vitis-idaea L., folia), rose hips (Rosa spp., fructus) and grass motherwort five-lobed or heart (Leonurus quinquelobatus Gilib. et L. cardiaca L., herba) in probably 55%, 15%, 15%, 15%, respectively. Research methods meet the requirements of the RF GF. Results. TAgar was chosen as a gelling agent for the dosage form, potassium sorbate as a preservative, and purified water as a solvent. The flavoring agent is erythritol. A method for determining inulin in a gel for oral administration has been developed. Conclusion. A technology for obtaining a gel for oral administration has been developed, including the stages of obtaining a gel base and introducing a thick extract into the resulting base. A technique has been developed for the determination of inulin in a gel for oral administration. The quality indica-tors of the gel with a thick extract for oral administration were established according to the main indicators: appearance, uniformity, pH value, authen-ticity, quantitative determination of the inulin content.
Keywords: 
gel for oral administration
thick extract
gel bases
medicinal collection.
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