INVESTIGATION OF THE BIOLOGICAL ACTIVITY OF MIXED-LIGAND COMPLEXES IN RELATION TO CONDITIONALLY PATHOGENIC STRAINS

Relevance. Flavonoids represent the largest group of natural molecules with antibacterial action, which can be explained by aggregation of bacterial cells and damage to the bacterial membrane. Modification of antimicrobial drugs with flavonoids may become a promising technique in the fight against antibiotic resistance, since the presence of complex structural complexes in the composition will help hide or reduce the recognition of antibac-terial substances by bacteria. The purpose of the work: To assess the change in morphometric parameters of bacterial cells of P. aeruginosa under the combined effect of anti-bacterial drugs and flavonoids of medicinal plant raw materials. Material and methods: The object of the study were strains of R. aeruginosa grown on meat-peptone agar, which were affected by complexes of flavonoids isolated from Dianthus and Folia eucalypti with antibacterial drugs fosfomycin and ceftazidime. Visualization of morphometric changes and physical characteristics of the object of study was carried out using AFM. Results. Analysis of the experimental data obtained indicates that combinations of flavonoids with ceftazidime significantly reduced bacterial cell length by 5.5% (p