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PROSPECTS FOR INNOVATIVE DRUGS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

DOI: https://doi.org/10.29296/25877313-2023-12-07
Issue: 
12
Year: 
2023

A.A. Romanycheva
Ph.D. (Biol.), Junior Research Scientist, Department of Pharmaceutical Development,
Center for Pharmaceutical Technology Transfer named after M.V. Dorogov,
Yaroslavl State Pedagogical University named after K.D. Ushinsky (Yaroslavl, Russia)
E-mail: kai-ren@yandex.ru
M.K. Korsakov
Dr.Sc. (Chem.), Associate Professor, Director of Center for Pharmaceutical Technology Transfer named after M.V. Dorogov,
Yaroslavl State Pedagogical University named after K.D. Ushinsky (Yaroslavl, Russia)
E-mail: mkkors@mail.ru
V.N. Fedorov
Dr.Sc. (Med.), Professor, Head of the Scientific Department of the Institute of Pharmacy,
Yaroslavl State Medical University (Yaroslavl, Russia)
E-mail: fedorov.vladimir@hotmail.com
A.A. Shetnev
Ph.D. (Chem.), Head of the Pharmaceutical Development Department,
Center for Pharmaceutical Technology Transfer named after M.V. Dorogov,
Yaroslavl State Pedagogical University named after K.D. Ushinsky (Yaroslavl, Russia)
E-mail: a.shetnev@yspu.org
A.V. Arshinov
Dr.Sc. (Med.), Professor, Head of Department Propaedeutics of Internal Diseases,
Yaroslavl State Medical University (Yaroslavl, Russia)
E-mail: a_arshinov@mail.ru

Rheumatoid arthritis is an immune-inflammatory disease with multifactorial etiology, affecting directly or indirectly all organs and systems of the body. Generally accepted standards of drug therapy of rheumatoid arthritis, represented by baseline anti-inflammatory drugs, glucocorticoids and non-steroidal anti-inflammatory drugs, have remained unchanged for a long time, but often they only alleviate or slow down the course of the disease, without curing the patient completely. Therefore, new pharmacologic targets for therapy are being actively investigated. A review of the literature concerning the development of innovative drugs for the treatment of rheumatoid arthritis is presented. The prospects for the development of new drugs based on inhibitors of Janus kinases, transcription factor NF-kB, mitogen-activated kinase p38, histone diethylase, phosphoinositide-3-kinase, low-molecular-weight antagonists of proteinase-activated PAR2 receptors, and anti-PAR-2-specific monoclonal antibodies are outlined.
Keywords: 
rheumatoid arthritis
antirheumatic drugs
potential therapeutic targets.
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