Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

MEDICINAL PLANTS WITH RESTORATIVE AND TONIC EFFECT IN THE REPUBLIC OF BURYATIA (REVIEW)

DOI: https://doi.org/10.29296/25877313-2024-01-01
Issue: 
1
Year: 
2024

P.G. Mizina
Dr.Sc. (Pharm.), Professor,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: mizina-pg@yandex.ru, ORCID: https://orcid.org/0000-0001-7494-2365
I.A. Lupanova
Ph.D. (Biol.), Head of pre-clinical studies center,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: lupanova@vilarnii.ru, ORCID: https://orcid.org/0000-0001-8183-2877
V.V. Karabaeva
Senior Researcher, Department of experimental pharmacology,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: vera-karabaeva@rambler.ru
E.V. Ferubko
D. (Med.), Head of the Department of experimental pharmacology,
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail: eferubko@yandex.ru, ORCID: https://orcid.org/0000-0003-1949-2597
O.A. Altaeva
Ph.D. (Agricul.), Associate Professor of the Department "General agriculture",
Buryat State Agricultural Academy named after V.R. Filippova (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: altaeva_olga@mail.ru
O.M. Cybikova
Ph.D. (Agricul.), Associate Professor, Head of the Department "Сrop production, Grassland and Horticulture",
Buryat State Agricultural Academy named after V.R. Filippova (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: oyuna_sodnom@rambler.ru
O.Yu. Davydova
Ph.D. (Biol.), Associate Professor of the Department "Сrop production, Grassland and Horticulture";
Deputy Editor-in-Chief of the journal "Vestnik BGSHA" (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: Vestnik_bgsha@bgsha.ru

Relevance. In many countries plants have long been used in folk medicine as a source of medicines, as they are well tolerated, gradual development of therapeutic effect and a mild effect on the body. Due to these features such medicines are being safely used in the treatment and prevention of exacerbations of chronic diseases: of cardiovascular system, respiratory system, digestive system, pathologies of the urinary tract, etc., and also as a rehabilitation therapy after past diseases. The purpose of the study is to systematize and generalize the data of world literature concerning the general health-improving and tonic properties study of plants growing in the Republic of Buryatia. Material and methods. In this work used publication materials from the PubMed and е-library databases, search.rsl. The keyword search: restorative, tonic effect, herbal medicines, medicinal plants of Buryatia, biologically active substances, Astragalus membranaceus, Saposhnikovia divaricatа, Scutellaria baicalensis, Sedum roseum, Crataegus sangunea. The survey comprises the data of foreign and national articles, published on the topic during last 20 years. Conclusions. All the plants listed in this review are used for thousands of years in the Tibetan medicine. Based on the analysis of the presented literature data, their range of medicinal use is much wider, then the applications in modern clinical practice. The information reported in this review may be the basis for the development of new herbal medicines, including officinal mixture, with specified pharmacological properties.

Keywords: 
Baikal region
medicinal plants
biological activity
Astragalus membranaceus
Saposhnikovia divaricatа
Scutellaria baicalensis
Sedum roseum
Crataegus sangunea.

References: 
  1. Studencev E.P., Ramsh S.M., Kazurova N.G. i dr. Adaptogeny i rodstvennye gruppy lekarstvennyh preparatov – 50 let poiskov. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. 2013; (11): 3–43.
  2. Sambuev D.N., Nikolaev S.M., Mathanov Je.I. i dr. Integracija tradicionnoj mediciny v sovremennoe zdravoohranenie Rossii. Vestnik Burjatskogo nauchnogo centra Sibirskogo otdelenija Rossijskoj akademii nauk. 2019; 3(35): 49–54. DOI: 10.31554/2222-9175-2019-35-10-49-53.
  3. Cicilin A.N. Astragal pereponchatyj – perspektivnoe lekarstvennoe rastenie. Rastenievodstvo i lugovodstvo: sbornik statej Vserossijskoj nauchnoj konferencii s mezhdunarodnym uchastiem, Moskva, 18–19 oktjabrja 2020 goda. Moskva: JejPiSiPablishing, 2020: 373–375. DOI: 10.26897/978-5-9675-1762-4-2020-82.
  4. Batocyrenova Je.T., Shantanova L.N., Cyrenzhapova O.D. Antigipoksicheskie svojstva suhogo jekstrakta astragala pereponchatogo. Bjulleten' VSNC SO RAMN. 2012; 4(86): 178–180.
  5. Turtueva T.A., Nikolaeva G.G., Guljaev S.M., Zhalsanov Ju.V. Aminokislotnyj sostav kornej Astragalus membranaceus (Fish.) Bunge. Vestnik Burjatskogo gosudarstvennogo universiteta. 2013; 12: 75–77.
  6. Fu J., Wang Z., Huang L., et al. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytotherapy Research. 2014; 28(9): 1275–1283. DOI: 10.1002/ptr.5188.
  7. Sheik A., Kim K., Varaprasad G.L. et al. The anti-cancerous activity of adaptogenic herb Astragalus membranaceus. Phytomedicine. 2021; 91: 153698. DOI: 10.1016/j.phy-med.2021.153698.
  8. Shahrajabian M.H., Sun W., Cheng Q. A review of Ast-ragalus species as foodstuffs, dietary supplements, a traditional Chinese medicine and a part of modern pharmaceutical science. Аpplied ecology and environmental research. 2019; 17(6): 13371–13382.
  9. Shurygina L.V., Kravcov A.A., Zlishheva Je.I. i dr. Vlijanie jekstraktov kornja i nadzemnoj chasti astragala pereponchatogo (Astragalus membranaceus (Fish.) Bunge) na nekotorye mehanizmy destruktivnyh processov, protekajushhih v nej. Vestnik VGU, serija: Himija. Biologija. Farmacija. 2014; 44: 149–153.
  10. Hou M., Leng Y., Shi Y., et al. Astragalus membranaceus as a drug candidate for inflammatory bowel disease: The Pre-clinical Evidence. The American journal of Chinese medi-cine. 2023; 51(6): 1501–1526. DOI: 10.1142/S0192415X23500684.
  11. Huang F., Xue W., Lan Yu., et al. Astragaloside IV sup-pressed hippocampal GABAergic synaptic transmission and enhanced memory through EGR‑1 mediated BDNF/TrkB signaling pathway in mice. Research Square. 2020; 2: 1–25. DOI: 10.21203/rs.3.rs‑35057/v2.
  12. Karetnikova A.Ju., Matvienko U.A., Savinova D.A. i dr. Vlijanie nastoja Astragalus membranaceus na obuchenie krys v radial'nom labirinte. Vestnik Rossijskogo universiteta druzhby narodov. Serija: Medicina. 2022; 26(1): 69–78. DOI: 10.22363/2313-0245-2022-26-1-69-78.
  13. Hobrakova V.B., Nikolaev S.M. Immunomodulirujushhie svojstva otvara astragala pereponchatogo. Sibirskoe medicinskoe obozrenie. 2009; 5(59): 45–48.
  14. Nikolaev S.M. Fitofarmakoterapija i fitofarmakoprofilaktika zabolevanij. Ulan-Udje: Izdatel'stvo Burjatskogo gosuniversiteta; 2012; 286 s.
  15. Edwards J.E., Brown P.N., Talent N. et al. A review of the chemistry of the genus Crataegus. Phytochemistry. 2012; 79: 5–26. DOI: 10.1016/j.phytochem.2012.04.006.
  16. Kurkin V.A., Morozova T.V., Shajhutdinov I.H. i dr. Sravnitel'noe fitohimicheskoe i mikrobiologicheskoe issledovanie zhidkih jekstraktov iz plodov bojaryshnika krovavo-krasnogo i bojaryshnika polumjagkogo. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2019; 22(4): 3−6. DOI: 10.29296/25877313-2019-04-01.
  17. Kurkin V.A., Kurkina A.V., Zajceva E.N. i dr. Diureticheskaja i antidepressantnaja aktivnost' gustogo jekstrakta bojaryshnika krovavo-krasnogo. Bjulleten' sibirskoj mediciny. 2015; 14(3): 18–22.
  18. Morozova T.V., Kurkina A.V., Pravdivceva O.E., Dubishhev A.V. Farmakognosticheskoe i farmakologicheskoe issledovanie syr'ja bojaryshnika Izvestija Samarskogo centra RAN. 2015; 17 (5): 959–63.
  19. Trofimova S.V., Hasanova S.R., Kudashkina N.V. Izuchenie antiaritmicheskoj aktivnosti list'ev Crataegus sanguinea (Rosaceae) Medicinskij vestnik Bashkortostana. 2011; 6(2): 299–302.
  20. Chernikova V.V. Rannjaja diagnostika serdechno-sosudistyh narushenij u bol'nyh s distroficheskoj miotoniej. Aspirantskij vestnik Povolzh'ja. 2014; 1-2: 75–77.
  21. Savchenko O.M., Cybul'ko N.S., Samatadze T.E. Sravnitel'noe izuchenie predstavitelej razlichnyh populjacij vida Sedum roseum (L.) Scop. pri vozdelyvanii v kul'ture. Jug Rossii: jekologija, razvitie. 2023; 18(2): 21–32. DOI: 10.18470/1992-1098-2023-2-21-32.
  22. Atlas lekarstvennyh rastenij Rossii. Izdatel'stvo: Federal'noe gosudarstvennoe unitarnoe predprijatie «Akademicheskij nauchno-izdatel'skij, proizvodstvenno-poligraficheskij i knigorasprostranitel'skij centr «Nauka» (Moskva), 2021; 646 с.
  23. Panossian A., Wikman G., Sarris J. Rosenoot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010; 17(7): 481–493. DOI: 10.1016/j.phymed.2010.02.002.
  24. Pu W.L., Zhang M.Y., Bai R.Y. et al. Anti-inflammatory effects of Rhodiola rosea L.: A review. Biomedicine and Pharmacotherapy. 2020; 121: 109552.
  25. Kurkin V.A., Rjazanova T.K. Voprosy standartizacii lekarstvennyh preparatov rodioly rozovoj. Farmacija i farmakologija. 2021; 9(3): 185–194. DOI: 10.19163/2307-9266-2021-9-3-185-194.
  26. Kurkin V.A., Zapesochnaja G.G. Himicheskij sostav i farmakologicheskie svojstva rastenij roda rodiola (obzor). Himiko-farmacevticheskij zhurnal.
  27. 1986; 20(10): 1231–1244.
  28. Anghelescu I.G., Edwards D., Seifritz E., Kasper S. Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice. 2018; 22(4): 242–252.
  29. Ivanova Stojcheva Е., Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions–Encouraging Clinical Evidence. Molecules. 2022; 27: 3902. DOI: 10.3390/molecules27123902.
  30. Marchev А., Dinkova-Kostova А., György Z. et al. Rhodiola rosea L.: from golden root to green cell factories. Phytochemistry Reviews. 2016; 15: 515–536. DOI: 10.1007/s11101-016-9453-5.
  31. Wu S., Zu Y., Wu M. High yield production of salidroside in the suspension culture of Rhodiola sachalinensis. J Biotechnol. 2003; 106(1): 33–43. DOI: 10.1016/j.jbiotec.2003.07.009.
  32. Asyakina L., Sukhikh S., Ivanova S. et al. Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of in vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea. Biomolecules. 2021; 11: 365. DOI:10.3390/biom11030365.
  33. Savina T.A., Mjasnikova S.B., Balakina M.V. Optimizacija uslovij vyrashhivanija supenzionnoj kul'tury rodioly rozovoj (Rhodiola Rosea L.). Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2016; 19(9): 13–17.
  34. Lupanova I.A., Mizina P.G., Ferubko E.V., Mjasnikova S.B. Izuchenie farmakologicheskoj aktivnosti jekstraktov iz suspenzionnyh kul'tur zhen'shenja obyknovennogo i rodioly rozovoj. Patologicheskaja fiziologija. 2023; 67(2): 77–85. DOI: 10.25557/0031-2991.2023.02.77-85.
  35. Urbagarova B.M., Taraskin V.V., Radnaeva L.D. Primenenie v medicine Saposhnikovia divaricata (Turcz.) Schischk. Vestnik Burjatskogo gosudarstvennogo universiteta. Medicina i farmacija. 2021; 1: 31‒39.
  36. Rastitel'nye resursy Rossii. Dikorastushhie cvetkovye rastenija, ih komponentnyj sostav i biologicheskaja aktivnost'. T. 3. Semejstva Fabaceae-Apiaceae. Otvetstvennyj redaktor A.L. Budancev. Sankt-Peterburg; Moskva: Tovarishhestvo nauchnyh izdanij KMK. 2020; 601 s.
  37. Rabdanova N.P., Urbagarova B.M., Taraskin V.V., Tyhe-ev Zh.A. Razrabotka sposoba poluchenija sapozhnikovii rastopyrennoj kornej nastojki – istochnika hromonov, ee standartizacija i opredelenie antiradikal'noj aktivnosti. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2022; 25(12): 37−43. DOI: 10.29296/25877313-2022-12-06.
  38. Yang M., Wang C.C., Wang W.L., et al. Saposhnikovia di-varicate – An ethnopharmacological, phytochemical and pharmacological review. Chinese Journal of Integrative Medicine. 2020 ;26(11); 873–880. DOI: 10.1007/s11655-020-3091-x.
  39. Tai J., Cheung S. Anti-proliferative and antioxidant activities of Saposhnikovia divaricate. Oncology Reports. 2007; 18: 227–234.
  40. Li L., Li B., Zhang H.R., et al. Ultrafi ltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients. Journal of Functional Foods. 2015;15: 389–395.
  41. Chun J.M., Kim H.S., Lee A.Y., et al. Anti-inflammatory and antiosteoarthritis effects of Saposhnikovia divaricata ethanol extract: in vitro and in vivo studies. Evidence-Based Complementary and Alternative Medicine. 2016; 2016: 1984238. DOI: 10.1155/2016/1984238.
  42. Urbagarova B.M., Taraskin V.V. Opredelenie summarnogo soderzhanija flavonoidov, dubil'nyh veshhestv i polisaharidov v Saposhnikoviae divaricatae Radices. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2019; 10(22): 25–29. DOI: 10.29296/25877313-2019-10-04.
  43. Cjerjensonom G., Njambajar H., Dorzhsurjen N., Chultjemsurjen E. i dr. Vlijanie rastitel'nogo preparata sapozhnikovii rastopyrennoj (Saposhnikovia divaricata (Trcz) Schis-schk)) na vyzvannoe kollagenom vospalenie sustavov v jeksperimente. Sibirskij medicinskij zhurnal (Irkutsk). 2015; 1: 106–108.
  44. Xue B.Y., Li W., Li L., Xiao Y.Q. A pharmacodynamic research on chromone glucosides of fangfeng. Zhongguo Zhong Yao Za Zhi. 2000; 25(5): 297–299.
  45. Khan S., Shin E.M., Choi R.J. et al. Suppression of LPS-induced inflammatory and NF-κB responses by anomalin in RAW 264.7 macrophages. Journal of Cellular Biochemistry. 2011; 112: 2179–2188. DOI: 10.1002/jcb.23137.
  46. Khan S., Shehzad O., Chan J., Kim Y.S. Mechanism underlying antihyperalgesic and anti-allodynic properties of anomalin in both acute and chronic infl amma-tory pain models in mice through inhibition of NF-κB, MAPKs and CREB signalling cascades. European Journal of Pharmacology. 2013; 718: 448–458. DOI: 10.1016/j.ejphar.2013.07.039.
  47. Li L., Gui Y.G., Shi D.F. Antioxidant activities of chromones from Saposhnikovia divaricate. Lishizhen Medicine and Materia Medica Research. 2010; 21: 2135–2137.
  48. Kuo Y.C., Lin Y.L., Huang C.P. et al. A tumor cell growth inhibitor from Saposhnikovae divaricate. Cancer Investigation. 2003; 20: 955–964. DOI: 10.1081/cnv-120005911.
  49. Wang X., Jiang X., Yu X. et al. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Journal of Cellular and Molecular Medicine. 2017; 20(10): 1‒11. DOI: 10.1111/jcmm.13204.
  50. Zhao T., Tang H., Xie L., et al. Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Pharm Pharmacol. 2019; 71(9): 1353–1369. DOI: 10.1111/jphp.13129.
  51. Бухашеева Т.Г. Scutellaria baicalensis Georgi – перспективное лекарственное растение. Вестник Бурятского государственного университета. 2008; 2: 56–59.
  52. Zhao Q., Chen X-Y., Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Science Bulletin. 2016; 61: 1391–1398. DOI: 10.1007/s11434-016-1136-5.
  53. Ji X.L. A review on chemical constituents and pharmacological effects of Radix Scutellariae. Journal of Chinese Clinical Medicine. 2017; 9: 128–129.
  54. Chenrui L., Lin G., Zuo Z. Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharmaceutics & Drug Disposition. 2011; 32: 427–445. DOI: 10.1002/bdd.771.
  55. Li H.B., Jiang Y., Chen F. Separation methods used for Scutellaria baicalensis active components. Journal of Chromato-graphy B. 2010; 812: 277–290. DOI: 10.1016/j.jchro-mb.2004.06.045.
  56. Heo H., Shin Y., Cho W., et al. Memory improvement in ibotenic acid-induced model rats by extracts of Scutellaria baicalensis. Journal of Ethnopharmacology. 2009; 122: 20–27. DOI: 10.1016/j.jep.2008.11.026.
  57. Jung H.S., Kim M.H., Gwak N.-G. et al. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro. Journal of Ethnopharmacology. 2012; 141: 345–349. DOI: 10.1016/j.jep.2012.02.044.
  58. Potapova A.A., Dorkina E.G., Sergeeva E.O. i dr. Vlijanie suhogo jekstrakta iz kornej shlemnika bajkal'skogo (Scutellaria baicalensis Georgi) na funkcional'noe sostojanie pecheni i pochek pri ih povrezhdenii ciklofosfanom v jeksperimente. Izvestija Samarskogo nauchnogo centra Rossijskoj akademii nauk. 2015; 17(5): 179–182.
  59. Shimizu I. Sho-Saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. Journal of Gastroenterology and Hepatology. 2010; 15: 84–90. DOI: 10.1046/j.1440-1746.2000.02138.x.
  60. Wu X., Zhi F., Lun W., et al. Baicalin inhibits PDGFBB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration, and activation via the miR-3595/ACSL4 axis. International Journal of Molecular Medicine.2018;41:1992–2002.
  61. Zhou Y., Hirotani M., Yoshikawa T., Furuya T. Flavonoids and phenyletha-noids from hairy root cultures of Scutellaria baicalensis. Phytochemistry.1997; 44: 83–87.