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HYPOLIPIDEMIC ACTIVITY OF THE PHYTOCOMPLEX OF THE HERB PHACELIA TANACETIFOLIA BENTH.

DOI: https://doi.org/10.29296/25877313-2024-01-09
Issue: 
1
Year: 
2024

P.A. Sheykhmagomedova
Post-graduate Student, Department of Pharmacognosy, Botany and Phytopreparation Technology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
E-mail: Patya16101998@yandex.ru
E.O. Sergeeva
Ph.D. (Pharm.), Associate Professor, Head of the Department of Microbiology and Immonology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
I.L. Abisalova
Ph.D. (Pharm.), Acting Head of the Department of Pathology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
L.A. Sajaya
Ph.D. (Pharm.), Associate Professor, Department of Pathology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
O.I. Popova
D.Sc. (Pharm.), Full Professor, Department of Pharmacognosy, Botany and Phytopreparation Technology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)
I.V. Popov
Ph.D. (Pharm.), Associate Professor, Department of Pharmacognosy, Botany and Phytopreparation Technology,
Pyatigorsk Medical and Pharmaceutical Institute – Branch of FSBEI HE VolgGMU
of the Ministry of Health of the Russian Federation (Pyatigorsk, Russia)

Introduction. The use of phenolic compounds as agents for preventing the risk of developing various cardiovascular diseases, as well as the prospect of creating new modern highly effective drugs based on them, is of current practical interest. The aim of the study is to identify the hypolipidemic activity of the phytocomplex of the herb Phacelia tanacetifolia Benth., and the possibility of its use in herbal preparations for the treatment of diseases of the cardiovascular system. Material and methods. The object of research was a herb of phacelia tanacetifolia, grown in the Neftekumsky region. The herb was collected during flowering and dried by air-shadowing method. The study of hypolipidemic activity was carried out on 24 white female Wistar rats weighing 270290 g. In the experiment, a Tween model of hyperlipidemia was created and used: a single intraperitoneal injection of Tween-80 at a dose of 250 mg / 100 g of body weight. Lipid profile analysis was carried out on a biochemical analyzer RAL CLIMA MC-15 using reagents from DiaSys, manufactured in Germa-ny. Results. Based on the level of triglycerides and very low density lipoproteins, it was found that the phytocomplex significantly exceeded the values of the reference drug (fenofibrate-canon). Conclusions. In conditions of twin hyperlipidemia, therapeutic and prophylactic administration of the Phacelia tanacetifolia phytocomplex at a dose of 300 mg/kg helps to normalize blood serum lipid metabolism.
Keywords: 
phenolcarboxylic acids
hypolipidemic activity
atherosclerosis
cardiovascular diseases.
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