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INFLUENCE OF LOPHANTHUS CHINENSIS DRY EXTRACT ON THE MORPHOFUNCTIONAL STATE OF WISTAR RATS THE BRAIN DURING LONG-TERM ALCOHOLIZATION

DOI: https://doi.org/10.29296/25877313-2024-05-08
Issue: 
5
Year: 
2024

Ya.G. Razuvaeva
Dr.Sc. (Biol.), Senior Research Scientist,
Institute of General and Experimental Biology SB RAS (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: tatur75@mail.ru
E.D. Khaltagarova
Post-graduate Student, Institute of General and Experimental Biology SB RAS;
Lecturer, Banzarov Buryat State University (Ulan-Ude, Republic of Buryatia, Russia)
Е-mail: haltik@yandex.ru

A.A. Toropova
Ph.D. (Biol.), Senior Research Scientist,
Institute of General and Experimental Biology SB RAS (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: anyuta-tor@mail.ru
K.V. Markova
Ph.D. (Med.), Senior Research Scientist,
Institute of General and Experimental Biology SB RAS (Ulan-Ude, Republic of Buryatia, Russia)
E-mail: kristen_kartland@mail.ru
D.N. Olennikov
Dr.Sc. (Pharm.), Head laboratory,
Institute of General and Experimental Biology SB RAS (Ulan-Ude, Republic of Buryatia, Russia)

The study purpose – to evaluate the effect of the Lophanthus chinensis dry extract on the Wistar rats brain morphofunctional state against the back-ground of long-term alcoholization. Material and methods. Alcohol intoxication was induced by long-term administration (6 weeks) of 40% ethanol in rats. Lophanthus chinensis dry ex-tract at a dose of 100 mg/kg was administered from the 3rd week of the experiment. On days 42-45, the animals were tested in an "open field", an el-evated plus maze, and they developed a conditioned passive avoidance reaction. After which a neurons pathomorphological study in the cerebral cor-tex was carried out. Results. It has been established that L. chinensis dry extract exhibits a neuroprotective effect during long-term alcohol intoxication, preventing the de-velopment of structural disorders in the cerebral cortex, thereby reducing anxiety and emotionality in animals, enhancing orientation-exploratory activity and normalizing mnestic functions. Conclusion. L. chinensis dry extract has a neuroprotective effect during long-term alcohol intoxication.
Keywords: 
Lophanthus chinensis dry extract
neuroprotective effect
alcohol intoxication
Wistar rats.
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