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PHYSIOLOGICAL AND TECHNOLOGICAL ASPECTS OF ERGOALKALOID BIOSYNTHESIS IN SAPROPHYTIC CULTURE THE CLAVICEPS PURPUREA (FR.) TULASNE (REVIEW)

DOI: https://doi.org/10.29296/25877313-2019-10-05
Issue: 
10
Year: 
2019

R.I. Bobyleva Ph.D. (Biol.), Leading Research Scientist, All-Russian Institute of Medicinal and Aromatic Plants (Moscow) E-mail: vilarnii@mail.ru P.S. Savin Ph.D. (Biol.), Leading Research Scientist, All-Russian Institute of Medicinal and Aromatic Plants (Moscow)

This review shows that to obtain high yields of ergoalkaloids (EA) in saprophytic culture, it is imperative to obtain highly productive strains of the Claviceps fungi  producers of peptide EA, which are stable in physiological and biochemical parameters. After obtaining the producer strain EA, it is necessary for it to create such nutrient media and cultivation conditions under which the realization of its potential possibilities will be most favorable. It is important to note that nutrient media and culture conditions are strain-specific and that the qualitative and quantitative composition of nutrient media, additional introduction of EA precursors into culture medium and culture conditions can stimulate the biosynthesis capacity of EA or suppress it.
Keywords: 
ergot alkaloids
funcus Claviceps
saprophytic culture
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