COMPARATIVE STUDY OF ANTIMICROBIAL ACTIVITY OF THE HERB OF MONARDA FISTULOSA L. AGAINST STRAINS FROM PATIENTS WITH MUCOVISCIDOSIS

DOI: https://doi.org/10.29296/25877313-2020-01-05
Issue: 
1
Year: 
2020

A.S. Lapina Post-graduate Student, Department of Pharmacognosy with Botany and the Basics of Phytotherapy, Samara State Medical University V.A. Kurkin Dr.Sc. (Pharm.), Professor, Head of the Department of Pharmacognosy with Botany and Basics of Phytotherapy, Samara State Medical University E-mail: kurkinvladimir@yandex.ru V.M. Ryzhov Ph.D.(Pharm.), Associate Professor, Department of Pharmacognosy with Botany and the Basics of Phytotherapy, Samara State Medical University A.V. Lyamin Ph.D.(Med.), Associate Professor, Department of General and Clinical Microbiology, Immunology and Allergology, Samara State Medical University O.V. Kondratenko Ph.D.(Med.), Associate Professor, Department of General and Clinical Microbiology, Immunology and Allergology, Samara State Medical University

The aim of the research is a comparative study of the antibacterial activity of samples of tinctures at various concentrations of ethyl alcohol and water infusion from Monarda fistulosa herbs against strains of mucoviscidosis. The article presents the results of a study of the antimicrobial activity of tinctures of Monarda fistulosaon 40%, 70%, 96% ethyl alcohol and water infusion of Monarda fistulosa against clinical strains mucoviscidosis: Burkholderia cenocepacia ST 208, Burkholderia multivorans, Pseudomonas aeruginosa. As a result of microbiological analysis, the bacteriostatic activity of tincture of Monarda fistulosa on 70% ethyl alcohol was detected against Burkholderia cenocepacia ST 208 and Burkholderia multivorans at a dilution of 1:32, that is exceed the activity of ethyl alcohol of the twice over. The tincture of Monarda fistulosa on 96% ethyl alcohol has a bactericidal effect against Burkholderia multivorans (strain 139) and bacteriostatic against Burkholderia cenocepacia ST 208 (strain 105), when is diluted 16 times; the lack of growth of this strain is observed at a dilution of 8 times. The water infusion of Monarda fistulosa most active against the strain 136 (Burkholderia cenocepacia ST 208).

Keywords: 
Monarda fistulosa L.
herb
tincture
water infusion
antimicrobial activity
mucoviscidosis

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