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ANTIOXIDANT ACTIVITY OF NEW DERIVATIVES OF CHROMОNЕ-3-ALDEHYDE IN CONDITIONS OF MUSCLE DYSFUNCTION

DOI: https://doi.org/10.29296/25877313-2018-06-07
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Issue: 
6
Year: 
2018

A.V. Voronkov Dr.Sc. (Med.), Associate Professor, Pyatigorsk Medical Pharmaceutical Institute-branch of the FSEI HE «Volgograd State Medical University» E-mail: prohor.77@mail.ru D.I. Pozdnyakov Lecturer, Pyatigorsk Medical Pharmaceutical Institute-branch of the FSEI HE «Volgograd State Medical University» E-mail: pozdniackow.dmitry@yandex.ru V.M. Rukovitsyna Post-graduate Student, Pyatigorsk Medical Pharmaceutical Institute-branch of the FSEI HE «Volgograd State Medical University» E-mail: rukovitcina.vika@mail.ru E.T. Oganesyan Dr.Sc. (Med.), Professor, Pyatigorsk Medical Pharmaceutical Institute-branch of the FSEI HE «Volgograd State Medical University» E-mail: edwardow@mail.ru

A study was conducted to assess the antioxidant activity of new derivatives of chromone-3-aldehyde in muscle dysfunction. Objects of the study were 5 new derived chromone-3-aldehyde Х3АNO2, Х3АОАС, Х3АN, Х3AF and X3ACL. Drug comparisons were made by Mexidol in a dose of 100 mg/kg. Studied compounds and drugs of comparison were administered per os, prophylactically for 7 days to muscle dysfunction. Muscle dysfunction was simu-lated by electromyostimulation method. Evaluated the change in the concentration of malonic dialdehyde, diene conjugates, superoxide dismutase activity, glutathione reductase activity, glutathione peroxidase activity, glukose-6-phosphate dehydrogenase and catalase activity. As a result, it was found that five compounds, which are based on the privileged nucleus of chromone, have antioxidant activity, expressed in inhi-bition of lipid peroxidation and the restoration of enzyme activity of endogenous antioxidant protection. The most pronounced antioxidant properties in several of the studied objects has a connection Х3АОАС, on the background of which the concentration of malondialdehyde and diene conjugates has de-creased by 2.6 times (p
Keywords: 
antioxidants
muscle dysfunction
oxidative stress
derivatives of chromone

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