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THE STRESS-PROTECTIVE AND ANTIOXIDANT EFFECT OF THE SCHIZONEPETA MULTIFIDA (L.) BRIQ. DRY EXTRACT

DOI: https://doi.org/10.29296/25877313-2018-07-02
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Issue: 
7
Year: 
2018

Ya.G. Razuvaeva, Dr.Sc. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude); Irkutsk State Medical Academy of Postgraduate Education − Branch Campus of the Russian Medical Academy of Continuing Professional Education E-mail: tatur75@mail.ru, D.V. Khargeev, Post-graduate Student, Institute of General and Experimental Biology SB RAS (Ulan-Ude), A.A. Toropova, Ph.D. (Biol.), Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude), D.N. Olennikov, Dr.Sc. (Pharm.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude)

The stress-protective and antioxidant effects of Schizonepeta multifida (L.) Briq. dry extract were estimated in the experiments on white Wistar rats. The stress-induced condition was simulated by immobilization of the animals for 24 hours. There was estimated the evidence of the Selye's triad (hypertrophy of adrenal glands, involution of thymus and spleen, and gastric mucous membrane ul-ceration, with the determination of the Pauls index), the content of MDA in the blood serum, the activity of catalase in the blood serum and SOD in erythrocytes and the content of the GSH in the blood. It has been revealed that the S. multifida dry extract in the dose of 200 mg/kg has a marked stress-protective effect, preventing the hypertrophy of the adrenal glands (by 30%), the involution of thy-mus and spleen (by 64 and 27% respectively). The S. multifida reduced the development of deep destruction of the gastric mucosa in white rats. The Pauls index for spot bleeding and erosions was on average by 64% lower than in the control. The animals in the exper-imental group had not striped ulcers. The S. multifida decreased the MDA content by 30%, increased the catalase activity the content of GSH, the activity of SOD by 34, 15 and 33% respectively as compared with the indices in the control group of animals. Thus, the S. multifida dry extract on the background of the immobilization stress has the stress-protective effect. The stress-protective effect of the tested remedy is due to its inhibiting influence on the processes of free radical oxidation and its capacity to activate the bodily sys-tem of antioxidant protection.
Keywords: 
Schizonepeta multifida (L.) Briq. dry extract
immobilization stress
stress-protective and antioxidant effects

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