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STOMACH CANCER STEM CELL BIOMARKERS

DOI: https://doi.org/10.29296/25877313-2018-10-02
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Issue: 
10
Year: 
2018

S.V. Chulkova Ph.D. (Med.), Senior Research Scientist, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of Russia (Moscow); N.I. Pirogov Russian National Research Institute, Ministry of Health of Russia (Moscow); ORCID: 0000-0003-4412-5019 E-mail: chulkova@mail.ru

Each own gland epithelium of the gastric mucosa consists of various specialized cells and a small number of discrete stem cells of the stomach that play a key role. They are capable of self-renewal, have multipotent properties and the source of specialized epithelium of the cells of the stomach. These properties determine the main role of stem cells in homeostasis, tissue repair and the development of malignant tumors. Subpopulations of cells with stem cell functions, so-called cancer stem cells (CSCs), are the source for the development of a malignant tumor of the stomach: they are at the very beginning of the origin, growth and spread of the tumor, and they are also responsible for resistance to traditional drug antitumor therapy.
Keywords: 
stomach cancer
gastric epithelial stem cells
bone marrow stem cells
CSCs
carcinogenesis
gene expression
resistance to the chemotherapy

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